Clomiphene Citrate in Infertile Men With Idiopathic Oligoasthenozoospermia

The Effect of Clomiphene Citrate on Sperm Parameters in Infertile Men With Idiopathic Oligoasthenozoospermia

The goal of this clinical trial is to learn if drug clomiphene citrate improves sperm parameters in infertile men with idiopathic oligoasthenozoospermia. It will also learn about the safety of clomiphene citrate. The main questions it aims to answer are:

• Does drug clomiphene citrate change sperm count and motility in infertile men with idiopathic oligoasthenozoospermia?
• What medical problems do participants have when taking drug clomiphene citrate? Researchers will compare drug clomiphene citrate to a placebo (a look-alike substance that contains no drug) to see if drug clomiphene citrate works to treat idiopathic oligoasthenozoospermia.

Inclusion Criteria:

• Infertile men
• Idiopathic oligoasthenozoospermia (serum FSH and serum LH range was 2-7 IU/mL and serum testosterone level was >300 ng/dl)

Exclusion Criteria:

• Azoospermia
• Body mass index <18 kg/m2 and >30 kg/m2
• Any abnormality on genital examination and scrotal sonogram
• History of genital diseases & genital surgery
• Medical and endocrine disorders like uncontrolled diabetes mellitus, severe kidney disease and liver insufficiency
• Psycho-sexual abnormalities
• Antioxidant supplements in previous 3 months
• Smoking, drug, alcohol or substance abuse
• History of chemotherapy or radiotherapy
• Presence of any gross female factor abnormality