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The efficacy of two intralesional treatment modalities for alopecia areata will be determined. Thirty patients over the age of 6 with the diagnosis of alopecia areata on the scalp, with an extension of less than 50%, will be included. A comparison will be made between the effectiveness of intralesional Triamcinolone (standard first-line treatment) and intralesional Candida albicans antigen, with serial clinical and trichoscopic pictures at follow-up to evaluate the clinical response and associated adverse effects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intralesional Triamcinolone | Active Comparator | Triamcinolone acetonide will be administered intralesionally at a concentration of 4 mg/mL. The solution will be injected in 0.1 mL doses, spaced 1 cm apart. The maximum total dose per session will be limited to 3 mL |
|
| Candida albicans antigen | Experimental | Single subcutaneous administration of 0.1 mL of Candida albicans antigen into one of the alopecic patches |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Candida Albicans Antigen Injection | Drug | subcutaneous administration of Candida albicans antigen |
|
| Measure | Description | Time Frame |
|---|---|---|
| Treatment response | porcentage of hair growth determined by SALT score | 5 months |
| Measure | Description | Time Frame |
|---|---|---|
| Side effects | Side effects associated to the treatment | 5 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Erika Alba-Rojas, MD | Contact | +528183891111 | eri9ar@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Fania Muñoz Garza, PhD | Hospital Universitario "Dr. José E. González" | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universitario "Dr. José Eleuterio González" | Recruiting | Monterrey | Nuevo León | 64460 | Mexico |
The database with the main clinical and trichoscopic results could be shared
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| ID | Term |
|---|---|
| D000506 | Alopecia Areata |
| ID | Term |
|---|---|
| D000505 | Alopecia |
| D007039 | Hypotrichosis |
| D006201 | Hair Diseases |
| D012871 | Skin Diseases |
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| D017437 |
| Skin and Connective Tissue Diseases |