The aim of this study is to evaluate the short-term effects of routinely applied agents on pain and joint range of motion (ROM) in ankle sprains presenting to the emergency department (ED).

It is aimed to examine the effects of intravenous (IV) 50 mg dexketoprofen, IV ibuprofen 400mg and IV paracetamol 10 mg on pain and joint range of motion. To determine the effects of these agents on pain, the easily applicable Numerical Rating Scale (NRS) and Wong-Baker Faces Pain Rating Scale will be used. A standard handheld half-circle goniometer will be utilized to calculate active ankle joint ROM.

Inclusion Criteria:

• Adults aged 18 years and older who present to the emergency department within the first 72 hours after ankle sprain.
• Grade 1 (mild) and Grade 2 (moderate) ankle sprains.
• Exclusion of fractures and dislocations (after X-ray according to Ottawa rules).
• Absence of muscle-tendon ruptures.
• Absence of vascular and nerve injuries.
• Absence of open wounds and burns.
• Stable vital signs.
• Patients who provide written and verbal consent.

Exclusion Criteria:

• Patients who did not present to the emergency department within the first 72 hours after ankle sprain.
• Grade 3 (severe) ankle sprains.
• Multiple traumas.
• Pregnancy or suspected pregnancy.
• Ankle fractures and dislocations.
• Forensic cases.
• History of previous ankle surgery or fracture.