Efficacy of Milrinone With Sildenafil in Persistent Pulmonary Hypertension in Children

Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates With Persistent Pulmonary Hypertension: A Single-Center, Randomized Controlled Trial

Neonates with persistent pulmonary hypertension (PPH) should be administered inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation (ECMO), but these are not available in most resource-constrained settings like ours. This study was planned to compare the outcomes of Milrinone plus Sildenafil versus Sildenafil alone in the treatment of PPH in neonates.

Inclusion Criteria:

• Patients of either gender
• Aged between 1-28 days
• Birth weight above 2000 grams
• Diagnosed with persistent pulmonary hypertension (as per echocardiography)

Exclusion Criteria:

• Neonates having congenital heart defects (CHDs)
• Congenital diaphragmatic hernia
• Lung anomalies
• History of any surgical intervention