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| ID | Type | Description | Link |
|---|---|---|---|
| 5P2CHD086844-10 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Medical University of South Carolina | OTHER |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
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The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS.
The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.
This project is the first of two projects. The second project will be registered as a separate project in the future and enroll participants from this project.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HD-tDCS with standard intervention | Experimental | Participants will have three daily sessions. |
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| Personalized dose-controlled multifocal network-targeted HD-tDCS. | Experimental | Participants will have three daily sessions. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard HD-tDCS intervention | Device | Participants will have three sessions along with behavioral assessments. |
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| Measure | Description | Time Frame |
|---|---|---|
| Percent change in precision force-tracking task | Squared distance (error) from the cursor to the target in precision force-tracking task, estimated as the root mean squared error (RMSE). | Baseline and 24 hours after the third sessions are completed |
| Percentage change in the time to complete the nine-hole peg test (9-HPT) | 9-hole peg test is a manual dexterity measure, estimated as the time required to complete the task (seconds). | Baseline and 24 hours after the third sessions are completed |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage change in the mean choice reaction time | Mean reaction time for subjects responding in the 2-choice reaction time control task, for correct responses | Baseline and 24 hours after the third sessions are completed |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael Vesia, PhD | Contact | 734-764-5237 | mvesia@umich.edu |
| Name | Affiliation | Role |
|---|---|---|
| Michael Vesia, PhD | University of Michigan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Michigan | Recruiting | Ann Arbor | Michigan | 48109 | United States |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Participants will be randomized and counterbalanced to arm 1 or arm 2.
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| Multifocal network targeted HD-tDCS intervention | Device | Participants will have three sessions along with behavioral assessments. |
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| Functional Magnetic Resonance Imaging (fMRI) | Device | Participants will have an MRI before or after having HD-tDCS intervention. |
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