Comparison of Intraperitoneal Bupivacaine Alone or With Dexmedetomidine

Comparison Between Mean Duration of Post-operative Analgesia of Intraperitoneal Bupivacaine Alone or With Dexmedetomidine Following Laparoscopic Cholecystectomy

For patients with symptomatic cholelithiasis, laparoscopic cholecystectomy (LC) is a customary procedure for treatment these days. After LC, patients may experience considerable pain. This study was performed with the objective of comparing the mean duration of analgesia of intraperitoneal bupivacaine with dexmedetomidine to intraperitoneal bupivacaine alone in patients undergoing laparoscopic cholecystectomy.

Inclusion Criteria:

• Patients of either gender
• Aged between 20 and 70 years
• ASA (American Society of Anesthesiologists Classification) physical status I and II
• Undergoing Laparoscopic Cholecystectomy under general anesthesia

Exclusion Criteria:

• Patients sensitive to local anesthetics
• Patients with acute cholecystitis, choledocholithiasis, or ascending cholangitis (temperature≥38.6°C, serum bilirubin≥1.2mg/dl, and ultrasound showing common bile duct diameter of ≥1cm).
• Patients with uncontrolled diabetes (FBS≥110 mg/dl)
• Uncontrolled blood pressure (SBP≥140 mmHg)
• Ischemic heart disease (EF≤40%)
• Pulmonary dysfunction (FEV≤70 percent of normal)