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| Name | Class |
|---|---|
| Medtronic | INDUSTRY |
| NAMSA | OTHER |
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Transcatheter aortic valve implantation (TAVI) is a key-hole technique to replace an aortic heart valve that is narrowed and/or leaking. Although TAVI is a safe and effective treatment for a faulty aortic heart valve, the new TAVI valve will not last forever. Because it is a 'tissue' valve (made from the lining of a cow or pig heart), the valve will fail after a period of time as the tissue degenerates.
When the TAVI valve fails, a viable treatment option is to perform a 'Redo TAVI' procedure, implanting a second TAVI valve inside the first failing valve.
The main purpose of this study is to carefully evaluate patients being treated by Redo TAVI in order to document the short-term and long-term outcomes of the procedure. The study will also obtain information about which factors predict those outcomes.
The study will also assess outcomes in patients who present with TAVI valve failure but are not suitable for Redo TAVI, and instead are treated either by open-heart surgery and surgical aortic valve replacement, or by medical therapy (medication).
The study will provide doctors the information they need to understand the best way to treat patients who present with TAVI valve failure, and in particular how to perform Redo TAVI procedures with the best possible outcomes for patients.
To determine the acute and long-term outcomes of Redo Transcatheter Aortic Valve Implantation (TAVI) for the treatment of Bioprosthetic Valve Failure (BVF) affecting Transcatheter Aortic Heart Valves (THVs)
To determine the factors which predict the acute and long-term outcomes of Redo TAVI
To determine the proportion of patients presenting with BVF affecting THVs who are deemed unsuitable for Redo TAVI by the Heart Team
To determine the acute and long-term outcomes of surgical explantation and aortic valve replacement (AVR) for the treatment of BVF affecting THVs
To determine the survival of patients presenting with BVF affecting THVs who are managed conservatively - including optimal medical therapy (OMT) +/- balloon aortic valvuloplasty (BAV)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Redo TAVI | Redo Trans-catheter Aortic Valve Implantation for Bioprosthetic Valve Failure of a Trans-catheter Aortic Valve |
| |
| Explant | Surgical explantation with aortic valve replacement |
| |
| Optimal Medical Therapy | Conservative treatment, including optimal medical therapy +/- balloon aortic valvuloplasty |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Any commercially available Edwards or Medtronic transcatheter aortic valve with the TAV-in-TAV (Redo TAVI) indication | Device | Redo TAVI will be performed using any commercially available Edwards or Medtronic transcatheter aortic valve platforms that have the TAV-in-TAV (Redo TAVI) indication according to the preferences of the local team in keeping with standard clinical care. |
| Measure | Description | Time Frame |
|---|---|---|
| REVALVE success (Redo TAVI) | Correct positioning of a single prosthetic heart valve into the proper anatomic location, intended performance of the valve (mean gradient <20mmHg, peak velocity <3 m/s, Doppler velocity index ≥0.25. aortic regurgitation < moderate), Freedom from mortality, coronary obstruction, unplanned coronary revascularisation, surgery or intervention related to the device | 30 days |
| Freedom from death/stroke/re-hospitalisation for valve or procedure-related causes (Redo TAVI) | Composite outcome of freedom from death/stroke/re-hospitalisation for valve or procedure-related causes | 12 months |
| Valve Academic Research Consortium 3 (VARC3) Early Safety (EXPLANT) | Composite outcome of freedom from: death/stroke/VARC 3-4 bleeding/major vascular, access-related, or cardiac structural complication/AKI 3 or 4/moderate or severe AR/new permanent pacemaker/device-related surgery or intervention | 30 days |
| Freedom from death/stroke/re-hospitalisation for valve or procedure-related causes (EXPLANT) | Composite outcome of freedom from death/stroke/re-hospitalisation for valve or procedure-related causes | 12 months |
| Freedom from death/stroke/re-hospitalisation for valve or procedure-related causes (OMT) | Composite outcome of freedom from death/stroke/re-hospitalisation for valve or procedure-related causes | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Valve Academic Research Consortium 3 (VARC3) Technical Success (Redo TAVI and EXPLANT) | Freedom from mortality, successful access, delivery of the device, and retrieval of the delivery system, correct positioning of a single prosthetic heart valve into the proper anatomical location, freedom from surgery or intervention related to the device or to a major vascular or access-related, or cardiac structural complication |
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Inclusion Criteria:
1. Bio-prosthetic Valve Failure (BVF) of a Transcatheter Aortic Valve requiring possible reintervention
Exclusion Criteria:
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All patients presenting to the Heart Team with bio-prosthetic valve failure affecting a transcatheter aortic valve
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dave Pickles | Contact | +441132433144 | dave.pickles@nhs.net | |
| Benaka Karanth | Contact | +44 1757 270044 | bkaranth@namsa.com |
| Name | Affiliation | Role |
|---|---|---|
| Daniel Blackman, MD | Leeds Teaching Hospitals NHS Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aalborg Universitethospital | Recruiting | Aalborg | Denmark | |||
| Ã…rhus Universitetshospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30883053 | Background | Popma JJ, Deeb GM, Yakubov SJ, Mumtaz M, Gada H, O'Hair D, Bajwa T, Heiser JC, Merhi W, Kleiman NS, Askew J, Sorajja P, Rovin J, Chetcuti SJ, Adams DH, Teirstein PS, Zorn GL 3rd, Forrest JK, Tchetche D, Resar J, Walton A, Piazza N, Ramlawi B, Robinson N, Petrossian G, Gleason TG, Oh JK, Boulware MJ, Qiao H, Mugglin AS, Reardon MJ; Evolut Low Risk Trial Investigators. Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients. N Engl J Med. 2019 May 2;380(18):1706-1715. doi: 10.1056/NEJMoa1816885. Epub 2019 Mar 16. | |
| 30883058 |
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| Surgical explantation and aortic valve replacement | Procedure | Surgical explantation of all or part of the index transcatheter aortic valve, with open implantation of a new surgical or transcatheter aortic valve replacement will be performed according to the preferences of the local team in keeping with standard clinical care. Any commercially available approved surgical or transcatheter aortic valve may be used. Additional surgery, such as aortic root replacement, root enlargement, CABG, mitral valve repair/replacement, etc. will be performed at the discretion of the local team. |
|
| Conservative management | Other | Conservative treatment, including optimal medical therapy +/- balloon aortic valvuloplasty |
|
| End of procedure |
| Valve Academic Research Consortium 3 (VARC3) Device Success (Redo TAVI and EXPLANT) | Technical success, Freedom from mortality, Freedom from surgery or intervention related to the device, or to a major vascular or access-related or cardiac structural complication, Intended performance of the valve (mean gradient <20 mmHg, peak velocity <3 m/s, Doppler velocity index ≥0.25, aortic regurgitation < moderate) | 30 days |
| Valve Academic Research Consortium 3 (VARC3) Early Safety (Redo TAVI) | Freedom from: death/stroke/VARC 2-4 bleeding (only VARC 3-4 for EXPLANT) /major vascular, access-related, or cardiac structural complication/Acute kidney injury (AKI) 3 or 4/moderate or severe Aortic Regurgitation/new permanent pacemaker/device-related surgery or intervention | 30 days |
| Peak and mean invasive gradient post-procedure (Redo TAVI) | Invasive pressure measurements | End of procedure |
| In-hospital Clinical Outcomes | All-cause mortality; All stroke; Myocardial infarction; Coronary artery obstruction; Unplanned coronary revascularisation (PCI or CABG); Bleeding (VARC 1-4); Major or minor Vascular and access-related complications; Cardiac structural complications; Permanent pacemaker implantation; Acute kidney injury (AKI) stage 1-4; Endocarditis; Clinically significant valve thrombosis | Immediately after the procedure/surgery |
| Echocardiographic Assessment: Peak velocity | Peak velocity | Pre-discharge or at 30 days, 1, 3, 5 years |
| Echocardiographic Assessment: Mean gradient | Mean gradient | Pre-discharge or at 30 days, 1, 3, 5 years |
| Echocardiographic Assessment: Aortic valve area | Aortic valve area | Pre-discharge or at 30 days, 1, 3, 5 years |
| Echocardiographic Assessment: Patient-prosthesis mismatch | Patient-prosthesis mismatch | Pre-discharge or at 30 days |
| Echocardiographic Assessment: Aortic Regurgitation - paravalvular, transvalvular or total | Aortic Regurgitation - paravalvular, transvalvular or total | Pre-discharge or at 30 days, 1, 3, 5 years |
| Echocardiographic Assessment: Left ventricular systolic function | Left ventricular systolic function | Pre-discharge or at 30 days, 1, 3, 5 years |
| Clinical Outcomes | All-cause mortality; Cardiovascular mortality; Valve-related mortality; Hospitalisation; Cardiovascular hospitalisation; Hospitalisation for valve or procedure-related causes; All stroke; Myocardial infarction; Coronary angiography; Coronary revascularization; Bioprosthetic valve dysfunction: i. Structural valve deterioration; ii. Non-structural valve deterioration (Prosthesis-patient mismatch, Paravalvular aortic regurgitation, Other) iii. Thrombosis iv. Endocarditis; Bioprosthetic valve failure; Aortic valve re-intervention | 1, 3 and 5 years |
| Recruiting |
| Aarhus |
| Denmark |
| Rigshospitalet | Recruiting | Copenhagen | Denmark |
| HUS Helsinki University Hospital | Recruiting | Helsinki | Finland |
| Turku University Hospital | Recruiting | Turku | Finland |
| Clinical Saint Augustin - Elsan | Recruiting | Bordeaux | France |
| Brest University Hospital Centre | Recruiting | Brest | France |
| Henri Mondor University Hospital | Recruiting | Créteil | France |
| ICPS Hôpital privé Jacques-Cartier | Recruiting | Massy | France |
| Centre Hospitalier Universitaire de Montpellier | Recruiting | Montpellier | France |
| University Hospital of Nimes | Recruiting | Nîmes | France |
| Hospital Marie Lannelongue | Recruiting | Paris | France |
| Institute Mutualiste Montsouris | Recruiting | Paris | France |
| Les Hospital Universitaires de Strasbourg | Recruiting | Strasbourg | France |
| Clinique Pasteur Toulouse | Recruiting | Toulouse | France |
| CHRU Hospitals of Tours | Recruiting | Tours | France |
| Medipole Lyon-Villeurbanne | Recruiting | Villeurbanne | France |
| Kerckhoff Klinik | Recruiting | Bad Nauheim | Germany |
| Herz- und Diabeteszentrum NRW | Recruiting | Bad Oeynhausen | Germany |
| Deutsches Herzzentrum Berlin | Withdrawn | Berlin | Germany |
| Universitatsklinikum Koln (AoR) | Recruiting | Cologne | Germany |
| Klinikum Dortmund GmbH - St. Johannes Hospital | Recruiting | Dortmund | Germany |
| Herzzentrum Dresden Universitätsklinik | Recruiting | Dresden | Germany |
| Universitatsklinikum Dusseldorf (University Hospital Dusseldorf) | Recruiting | Düsseldorf | Germany |
| Universitatsklinikum Frankfurt | Recruiting | Frankfurt | Germany |
| Asklepios Klinik St. Georg | Recruiting | Hamburg | Germany |
| Universitätsklinikum Schleswig-Holstein (UKSH) | Recruiting | Kiel | Germany |
| HELIOS Herzzentrum Leipzig GmbH | Recruiting | Leipzig | Germany |
| Universitätsklinikum Schleswig-Holstein (UKSH) | Recruiting | Lübeck | Germany |
| LMU Klinikum | Recruiting | München | Germany |
| Universitatsklinikum Ulm (University Hospital Ulm) | Recruiting | Ulm | Germany |
| Edith Wolfson Medical Center | Recruiting | Holon | Israel |
| Shaare Zedek Medical Center | Recruiting | Jerusalem | Israel |
| Rabin Medical Center - Belinson Campus | Recruiting | Petah Tikva | Israel |
| ASST Spedali Civili Di Brescia | Recruiting | Brescia | Italy |
| Fondazione Poliambulanza Istituto Ospedaliero | Recruiting | Brescia | Italy |
| Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele | Recruiting | Catania | Italy |
| Ospedale San Martino - IRCCS Ospedale Policlinico | Recruiting | Genova | Italy |
| Centro Cardiologico Monzino | Recruiting | Milan | Italy |
| Humanitas Research Hospital - RCCS Istituto Clinico Humanitas di Milano | Withdrawn | Milan | Italy |
| IRCCS Ospedale San Raffaele | Recruiting | Milan | Italy |
| Istituto Mediterraneo per i Trapianti Ismett IRCCS | Recruiting | Palermo | Italy |
| IRCSS Policlinico San Donato | Recruiting | San Donato Milanese | Italy |
| Azienda Ospedaliera Ordine Mauriziano di Torino | Recruiting | Torino | Italy |
| Ospedale Borgo Trento - Azienda Ospedaliera Universitaria Integrata Verona | Recruiting | Verona | Italy |
| Amphia Hospital | Recruiting | Breda | Netherlands |
| Maastricht University Medical Center (MUMC) | Recruiting | Maastricht | Netherlands |
| Radboud Universitair Medisch Centrum | Withdrawn | Nijmegen | Netherlands |
| Erasmus University Medical Center | Recruiting | Rotterdam | Netherlands |
| Haukeland Sykehus | Recruiting | Bergen | Norway |
| Oslo University Hospital | Recruiting | Oslo | Norway |
| Sahlgrenska University Hospital | Recruiting | Gothenburg | Sweden |
| Skånes Universitetssjukhus Lund | Recruiting | Lund | Sweden |
| Nya Karolinska Sjukhuset Solna | Recruiting | Solna | Sweden |
| Uppsala University | Recruiting | Uppsala | Sweden |
| Inselspital - Universitätsspital Bern | Recruiting | Bern | Switzerland |
| Luzerner Kantonsspital | Recruiting | Lucerne | Switzerland |
| Queen Elizabeth Hospital | Recruiting | Birmingham | United Kingdom |
| Royal Sussex County Hospital | Recruiting | Brighton | BN2 1ES | United Kingdom |
| Bristol Royal Infirmary | Recruiting | Bristol | United Kingdom |
| University Hospital of Wales | Recruiting | Cardiff | CF14 4XW | United Kingdom |
| Golden Jubilee National Hospital | Recruiting | Glasgow | United Kingdom |
| Leeds Teaching Hospitals NHS Trust | Recruiting | Leeds | LS1 3EX | United Kingdom |
|
| Glenfield Hospital | Recruiting | Leicester | United Kingdom |
| Guys and St Thomas' NHS Foundation Trust | Recruiting | London | United Kingdom |
| St. George's Hospital | Recruiting | London | United Kingdom |
| Manchester Royal Infirmary | Recruiting | Manchester | United Kingdom |
| Freeman Hospital | Recruiting | Newcastle upon Tyne | United Kingdom |
| Oxford University Hospitals NHS Foundation Trust | Recruiting | Oxford | OX3 9DU | United Kingdom |
| University Hospital Southampton NHS Foundation Trust | Recruiting | Southampton | SO16 6YD | United Kingdom |
| New Cross Hospital | Recruiting | Wolverhampton | United Kingdom |
| Background |
| Mack MJ, Leon MB, Thourani VH, Makkar R, Kodali SK, Russo M, Kapadia SR, Malaisrie SC, Cohen DJ, Pibarot P, Leipsic J, Hahn RT, Blanke P, Williams MR, McCabe JM, Brown DL, Babaliaros V, Goldman S, Szeto WY, Genereux P, Pershad A, Pocock SJ, Alu MC, Webb JG, Smith CR; PARTNER 3 Investigators. Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients. N Engl J Med. 2019 May 2;380(18):1695-1705. doi: 10.1056/NEJMoa1814052. Epub 2019 Mar 16. |
| 34453165 | Background | Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, Capodanno D, Conradi L, De Bonis M, De Paulis R, Delgado V, Freemantle N, Gilard M, Haugaa KH, Jeppsson A, Juni P, Pierard L, Prendergast BD, Sadaba JR, Tribouilloy C, Wojakowski W; ESC/EACTS Scientific Document Group. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022 Feb 12;43(7):561-632. doi: 10.1093/eurheartj/ehab395. No abstract available. |
| 33332149 | Background | Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP 3rd, Gentile F, Jneid H, Krieger EV, Mack M, McLeod C, O'Gara PT, Rigolin VH, Sundt TM 3rd, Thompson A, Toly C. 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021 Feb 2;143(5):e35-e71. doi: 10.1161/CIR.0000000000000932. Epub 2020 Dec 17. |
| 33284653 | Background | Fukuhara S, Brescia AA, Deeb GM. Surgical Explantation of Transcatheter Aortic Bioprostheses: An Analysis From the Society of Thoracic Surgeons Database. Circulation. 2020 Dec 8;142(23):2285-2287. doi: 10.1161/CIRCULATIONAHA.120.050499. Epub 2020 Dec 7. No abstract available. |
| 34556271 | Background | Bapat VN, Zaid S, Fukuhara S, Saha S, Vitanova K, Kiefer P, Squiers JJ, Voisine P, Pirelli L, von Ballmoos MW, Chu MWA, Rodes-Cabau J, DiMaio JM, Borger MA, Lange R, Hagl C, Denti P, Modine T, Kaneko T, Tang GHL; EXPLANT-TAVR Investigators. Surgical Explantation After TAVR Failure: Mid-Term Outcomes From the EXPLANT-TAVR International Registry. JACC Cardiovasc Interv. 2021 Sep 27;14(18):1978-1991. doi: 10.1016/j.jcin.2021.07.015. |
| 30025572 | Background | Tuzcu EM, Kapadia SR, Vemulapalli S, Carroll JD, Holmes DR Jr, Mack MJ, Thourani VH, Grover FL, Brennan JM, Suri RM, Dai D, Svensson LG. Transcatheter Aortic Valve Replacement of Failed Surgically Implanted Bioprostheses: The STS/ACC Registry. J Am Coll Cardiol. 2018 Jul 24;72(4):370-382. doi: 10.1016/j.jacc.2018.04.074. |
| 34092097 | Background | Testa L, Agnifili M, Van Mieghem NM, Tchetche D, Asgar AW, De Backer O, Latib A, Reimers B, Stefanini G, Trani C, Colombo A, Giannini F, Bartorelli A, Wojakowski W, Dabrowski M, Jagielak D, Banning AP, Kharbanda R, Moreno R, Schofer J, van Royen N, Pinto D, Serra A, Segev A, Giordano A, Brambilla N, Popolo Rubbio A, Casenghi M, Oreglia J, De Marco F, Tanja R, McCabe JM, Abizaid A, Voskuil M, Teles R, Biondi Zoccai G, Bianchi G, Sondergaard L, Bedogni F. Transcatheter Aortic Valve Replacement for Degenerated Transcatheter Aortic Valves: The TRANSIT International Project. Circ Cardiovasc Interv. 2021 Jun;14(6):e010440. doi: 10.1161/CIRCINTERVENTIONS.120.010440. Epub 2021 Jun 7. |
| 33413929 | Background | Landes U, Sathananthan J, Witberg G, De Backer O, Sondergaard L, Abdel-Wahab M, Holzhey D, Kim WK, Hamm C, Buzzatti N, Montorfano M, Ludwig S, Conradi L, Seiffert M, Guerrero M, El Sabbagh A, Rodes-Cabau J, Guimaraes L, Codner P, Okuno T, Pilgrim T, Fiorina C, Colombo A, Mangieri A, Eltchaninoff H, Nombela-Franco L, Van Wiechen MPH, Van Mieghem NM, Tchetche D, Schoels WH, Kullmer M, Tamburino C, Sinning JM, Al-Kassou B, Perlman GY, Danenberg H, Ielasi A, Fraccaro C, Tarantini G, De Marco F, Redwood SR, Lisko JC, Babaliaros VC, Laine M, Nerla R, Castriota F, Finkelstein A, Loewenstein I, Eitan A, Jaffe R, Ruile P, Neumann FJ, Piazza N, Alosaimi H, Sievert H, Sievert K, Russo M, Andreas M, Bunc M, Latib A, Godfrey R, Hildick-Smith D, Chuang MA, Blanke P, Leipsic J, Wood DA, Nazif TM, Kodali S, Barbanti M, Kornowski R, Leon MB, Webb JG. Transcatheter Replacement of Transcatheter Versus Surgically Implanted Aortic Valve Bioprostheses. J Am Coll Cardiol. 2021 Jan 5;77(1):1-14. doi: 10.1016/j.jacc.2020.10.053. |
| 33272031 | Background | Forrestal BJ, Case BC, Yerasi C, Shea C, Torguson R, Zhang C, Ben-Dor I, Deksissa T, Ali S, Satler LF, Shults C, Weissman G, Wang JC, Khan JM, Waksman R, Rogers T. Risk of Coronary Obstruction and Feasibility of Coronary Access After Repeat Transcatheter Aortic Valve Replacement With the Self-Expanding Evolut Valve: A Computed Tomography Simulation Study. Circ Cardiovasc Interv. 2020 Dec;13(12):e009496. doi: 10.1161/CIRCINTERVENTIONS.120.009496. Epub 2020 Dec 4. |
| 33213747 | Background | Ochiai T, Oakley L, Sekhon N, Komatsu I, Flint N, Kaewkes D, Yoon SH, Raschpichler M, Patel V, Tiwana R, Enta Y, Mahani S, Kim Y, Stegic J, Chakravarty T, Nakamura M, Cheng W, Makkar R. Risk of Coronary Obstruction Due to Sinus Sequestration in Redo Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. 2020 Nov 23;13(22):2617-2627. doi: 10.1016/j.jcin.2020.09.022. |
| 35926921 | Background | Landes U, Richter I, Danenberg H, Kornowski R, Sathananthan J, De Backer O, Sondergaard L, Abdel-Wahab M, Yoon SH, Makkar RR, Thiele H, Kim WK, Hamm C, Buzzatti N, Montorfano M, Ludwig S, Schofer N, Voigtlaender L, Guerrero M, El Sabbagh A, Rodes-Cabau J, Mesnier J, Okuno T, Pilgrim T, Fiorina C, Colombo A, Mangieri A, Eltchaninoff H, Nombela-Franco L, Van Wiechen MPH, Van Mieghem NM, Tchetche D, Schoels WH, Kullmer M, Barbanti M, Tamburino C, Sinning JM, Al-Kassou B, Perlman GY, Ielasi A, Fraccaro C, Tarantini G, De Marco F, Witberg G, Redwood SR, Lisko JC, Babaliaros VC, Laine M, Nerla R, Finkelstein A, Eitan A, Jaffe R, Ruile P, Neumann FJ, Piazza N, Sievert H, Sievert K, Russo M, Andreas M, Bunc M, Latib A, Bruoha S, Godfrey R, Hildick-Smith D, Barbash I, Segev A, Maurovich-Horvat P, Szilveszter B, Spargias K, Aravadinos D, Nazif TM, Leon MB, Webb JG. Outcomes of Redo Transcatheter Aortic Valve Replacement According to the Initial and Subsequent Valve Type. JACC Cardiovasc Interv. 2022 Aug 8;15(15):1543-1554. doi: 10.1016/j.jcin.2022.05.016. Epub 2022 Jul 13. |
| 33213826 | Background | Carroll JD, Mack MJ, Vemulapalli S, Herrmann HC, Gleason TG, Hanzel G, Deeb GM, Thourani VH, Cohen DJ, Desai N, Kirtane AJ, Fitzgerald S, Michaels J, Krohn C, Masoudi FA, Brindis RG, Bavaria JE. STS-ACC TVT Registry of Transcatheter Aortic Valve Replacement. Ann Thorac Surg. 2021 Feb;111(2):701-722. doi: 10.1016/j.athoracsur.2020.09.002. Epub 2020 Nov 16. |
| 40393632 | Derived | Blackman DJ, Aktaa S, Pickles D, Abdel-Wahab M, De Backer O, Van Mieghem NM, Treede H, Landes U, Bapat V, Hildick-Smith D, Barbanti M. REdo transcatheter aortic VALVE implantation for the management of transcatheter aortic valve failure: Design and rationale of the REVALVE study. Int J Cardiol. 2025 Sep 15;435:133400. doi: 10.1016/j.ijcard.2025.133400. Epub 2025 May 18. |
| ID | Term |
|---|---|
| D001024 | Aortic Valve Stenosis |
| ID | Term |
|---|---|
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014694 | Ventricular Outflow Obstruction |
Not provided
Not provided
| ID | Term |
|---|---|
| D000072700 | Conservative Treatment |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
Not provided
Not provided