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Can Electrical Cardioversion (ECV) for AF be improved. It is the preferred method to restore sinus rhythm in patients with AF in whom a rhythm-control strategy is pursued.
Hypothesis:
ECV success rates will be greater with a biphasic defibrillator with maximum energy of 360J (® Physio-Control) compared to a biphasic defibrillator with maximum energy of 200J (® Zoll)
Published estimates of ECV success using modern biphasic defibrillators vary considerably but most are limited by small sample sizes. Our pre-intervention ECV success rate of 91.8% was stable over >2.5 years and is comparable to a previous study from our institute11 and to recent estimates from moderately sized studies using contemporary technology. For instance, the Euro Heart Survey on AF reported an ECV success rate of 91% in 424 patients2 and the Biphasic Energy Selection for Transthoracic cardioversion of Atrial Fibrillation (BEST AF) trial reported 89% success in 380 patients.3 The variability in starting shock energy and shock energy escalation observed at our centre prior to implementing the OAFCP is also consistent with reported practices elsewhere. A recent survey of 57 European centres found that nearly two-thirds of hospitals started with a 100 J biphasic shock for AF whereas the remaining third started with 200 J.1 Considerable differences in electrode placement were also reported in this survey with 58.7% of centres using an anterolateral position and the remainder using an anteroposterior approach.1Our investigators and others have previously shown that physicians seldom apply sufficient force even when prompted to do so and even when using handheld paddles.10,16,17 ECV practices at our institute prior to implementing the OAFCP were therefore likely representative of those at most centres.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 200J | Active Comparator | biphasic defibrillator with maximum energy of 200J (® Zoll) |
|
| 360J | Active Comparator | biphasic defibrillator with maximum energy of 360J (® Physio-Control) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biphasic defibrillator with maximum energy of 200J (® Zoll) | Device | Cardioversion |
| |
| Measure | Description | Time Frame |
|---|---|---|
| ECV success | ECV success defined as >_2 consecutive sinus beats, or captured atrial-paced beats in patients with implanted cardiac devices, after shock delivery | 2 seconds |
| Measure | Description | Time Frame |
|---|---|---|
| First shock success | Cardioversion is successful without crossover | 2 seconds |
| sustained success | sustained sinus or atrial paced rhythm documented on 12-lead electrocardiogram |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tammy Knight | Contact | 613-696-7000 | 19080 | tknight@ottawaheart.ca |
| David Birnie | Contact | 613-696-7000 | dbirnie@ottawaheart.ca |
| Name | Affiliation | Role |
|---|---|---|
| Mehrdad Golian | Ottawa Heart Institute Research Corporation | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Ottawa Heart Institute | Recruiting | Ottawa | Ontario | K1Y 4W7 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42327430 | Derived | Golian M, Ramirez FD, Cleland M, Aydin A, Green MS, Klein A, Nair G, Nery P, Redpath C, Davis D, Hansom SP, Li Z, Wells GA, Birnie DH. MAX-SHOCK: A Pragmatic Randomized Controlled Trial Comparing Biphasic Defibrillators Used in Routine Cardioversion of Atrial Fibrillation. CJC Open. 2026 Mar 7;8(6):710-714. doi: 10.1016/j.cjco.2026.02.022. eCollection 2026 Jun. |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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two arms will be compared using the Chi squared test
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participants will not know which defibrillator was used during their cardioversion.
| biphasic defibrillator with maximum energy of 360J (® Physio-Control) |
| Device |
Cardioversion |
|
| 4 hours |
| D013568 |
| Pathological Conditions, Signs and Symptoms |