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| Name | Class |
|---|---|
| Peking Union Medical College Hospital | OTHER |
| West China Hospital | OTHER |
| First Affiliated Hospital of Wenzhou Medical University | OTHER |
| Ningbo Medical Center Lihuili Hospital |
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The investigators carried out a multi-center comparative study, involving hospitals including the Second Affiliated Hospital of Zhejiang University School of Medicine, Peking Union Medical College Hospital, West China Hospital, Wenzhou First Hospital, and Li Huili Hospital. This study aimed to compare the efficacy of medication and surgery for specific subtypes of microadenomas and clearly defined macroadenomas (Knosp grades 0-2), in order to determine which is more effective and which has fewer benefits, thereby enhancing the evidence base.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Operation group | Experimental | Transnasal transsphenoidal pituitary lesion resection under neuroendoscopy |
|
| Drug group | Active Comparator | Bromocriptin 2.5mg, 2-3 times a day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transnasal transsphenoidal pituitary lesion resection under neuroendoscopy | Procedure | Transnasal transsphenoidal pituitary lesion resection under neuroendoscopy |
|
| Measure | Description | Time Frame |
|---|---|---|
| pituitary hormone levels | Recheck pituitary hormones (PRL, GH, ACTH, etc.) | At 1, 3, 6, 9 and 12 months postoperatively |
| pituitary MRI | Recheck pituitary MRI | At 1,6 and 12 months postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| sexual function evaluation | Male:International Index of Erectile Function (IIEF-5); Female:Female Sexual Function Index (FSFI) | At 1,6 and 12 months postoperatively |
| menstrual condition | There is currently no specific "Pituitary Tumor Menstrual Status Questionnaire" for evaluation. The investigators usually evaluate the impact of pituitary tumors on menstruation based on the participants clinical symptoms and the results of sex hormones |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Qun Wu, Doctor | Contact | +86-13605810393 | 2192010@zju.edu.cn |
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| ID | Term |
|---|---|
| D010911 | Pituitary Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D007029 | Hypothalamic Neoplasms |
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| ID | Term |
|---|---|
| D001971 | Bromocriptine |
| ID | Term |
|---|---|
| D004879 | Ergotamines |
| D004876 | Ergot Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
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| OTHER_GOV |
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| Bromocriptin 2.5mg, 2-3 times a day | Drug | Bromocriptin 2.5mg, 2-3 times a day |
|
| At 6 and 12 months postoperatively |
| lactation | Serum prolactin levels | At 1,6 and 12 months postoperatively |
| D015173 |
| Supratentorial Neoplasms |
| D001932 | Brain Neoplasms |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D007027 | Hypothalamic Diseases |
| D010900 | Pituitary Diseases |
| D004700 | Endocrine System Diseases |
| D004873 |
| Ergolines |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |