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Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory tests.
Prior studies have reported that supplemental oxygen can confer acute benefits to cognition. Here, the investigators seek to replicate/extend such findings by assessing whether such benefits can be seen using an Inogen oxygen concentrator with subjects with an average age around 65 years old. The investigators include a standard measure of cognition previously reported to be sensitive to supplemental oxygen (2-back test) and a novel, in-development adaptation of a memory test for medical-related content (Medical icons spatial test).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Air First | Other | All study participants, completing memory tests while breathing either supplemental oxygen followed by air, or breathing air followed oxygen. |
|
| Oxygen First | Other | All study participants, completing memory tests while breathing either supplemental oxygen followed by air, or breathing air followed oxygen. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cross Over Assignment Supplemental Oxygen and Supplemental Air | Device | Subjects repeatedly complete memory tests, either first while breathing supplemental oxygen or first while breathing "supplemental air" (in an order randomly assigned). |
| Measure | Description | Time Frame |
|---|---|---|
| 2 back Memory test performance | # correct on 2-back test | At baseline and 5 mins post-intervention exposure |
| Memory test performance | New Medical Icons Spatial Test | At baseline and 5 mins post-intervention exposure |
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Inclusion Criteria:
Subjects are intended to represent "healthy adults." Patients will include a mix of self-reported gender and ethnic/racial identification.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marc Egeth | Inogen Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Two Liberty Place | Philadelphia | Pennsylvania | 19102 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22817401 | Background | Choi MH, Kim HJ, Kim JH, Kim HS, Choi JS, Yi JH, Tack GR, Chung YS, Son I, Chung SC. Correlation between cognitive ability measured by response time of 1-back task and changes of SpO2 by supplying three different levels of oxygen in the elderly. Geriatr Gerontol Int. 2013 Apr;13(2):384-7. doi: 10.1111/j.1447-0594.2012.00911.x. Epub 2012 Jul 23. | |
| 17395994 |
| Label | URL |
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| ID | Term |
|---|---|
| D018496 | Hyperoxia |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Acute effects of oxygen on memory testing in healthy adult volunteers
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| Chung SC, Kwon JH, Lee HW, Tack GR, Lee B, Yi JH, Lee SY. Effects of high concentration oxygen administration on n-back task performance and physiological signals. Physiol Meas. 2007 Apr;28(4):389-96. doi: 10.1088/0967-3334/28/4/005. Epub 2007 Mar 7. |
| 28111267 | Background | McMorris T, Hale BJ, Barwood M, Costello J, Corbett J. Effect of acute hypoxia on cognition: A systematic review and meta-regression analysis. Neurosci Biobehav Rev. 2017 Mar;74(Pt A):225-232. doi: 10.1016/j.neubiorev.2017.01.019. Epub 2017 Jan 19. |
| 15684544 | Background | Sohn JH, Chung SC, Jang EH. 30% oxygen inhalation enhances cognitive performance through robust activation in the brain. J Physiol Anthropol Appl Human Sci. 2005 Jan;24(1):51-3. doi: 10.2114/jpa.24.51. |
| 37121344 | Background | Shaw DM, Bloomfield PM, Gant N. The effect of acute normobaric hyperoxia on cognition: A systematic review, meta-analysis and meta-regression. Physiol Behav. 2023 Aug 1;267:114208. doi: 10.1016/j.physbeh.2023.114208. Epub 2023 Apr 29. |
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