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The purpose of this study is to compare the efficacy of GentleWave versus EdgePro irrigation in the disinfection of infected root canals of human permanent teeth with necrotic pulp.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GentleWave | Experimental |
| |
| EdgePro | Experimental |
| |
| Irrisafe passive ultrasonic irrigation | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GentleWave | Device | Root canals will be shaped using a Vortex Blue and ProTaper gold rotary system. Once the root canals have been shaped, the GentleWave procedure will be performed |
| Measure | Description | Time Frame |
|---|---|---|
| Bacterial count reduction checked by 16 S rDNA next-generation sequencing analysis (NGS) | Baseline, after cleaning and shaping of the root canal (about 30 minutes after baseline) |
| Measure | Description | Time Frame |
|---|---|---|
| Presence of proteolytic versus non-proteolytic bacteria in the root canals | Baseline, after cleaning and shaping of the root canal (about 30 minutes after baseline) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David Jaramillo, DDS | Contact | (713) 486-4224 | David.E.Jaramillo@uth.tmc.edu | |
| Ahmed Shehab-Eldin | Contact | (713) 486-4224 | Ahmed.ShehabEldin@uth.tmc.edu |
| Name | Affiliation | Role |
|---|---|---|
| David Jaramillo, DDS | The University of Texas Health Science Center, Houston | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas Health Science Center at Houston | Recruiting | Houston | Texas | 77030 | United States |
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| ID | Term |
|---|---|
| D003790 | Dental Pulp Necrosis |
| ID | Term |
|---|---|
| D003788 | Dental Pulp Diseases |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D009336 | Necrosis |
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| EdgePro laser irrigation | Device | Root canals will be shaped using a Vortex Blue and ProTaper gold rotary system. Once the root canals have been shaped, the EdgePro procedure will be performed |
|
| Irrisafe passive ultrasonic irrigation | Device | Root canals will be shaped using a Vortex Blue and ProTaper gold rotary system. Once the root canals have been shaped, the passive ultrasonic irrigation procedure will be performed |
|
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |