Based on the nutritional factor prediction model, the individualized nutritional management of patients with umbilical cord blood transplantation (UCBT) was carried out to observe the impact on the survival efficacy of patients.

The data of 80 UCBT patients were analyzed retrospectively, and the influence of nutritional parameters on the clinical outcome of UCBT patients was first confirmed, the skinfold thickness ≥20.5 mm and peripheral blood Alb < 33.6 g/L at 30 days after transplantation were the independent influencing factors of OS and DFS. In order to further verify the accuracy of the survival prediction model, the center intends to base on the model and aim at the nutritional parameters of patients 30 days after transplantation, a single-arm, single-center, phase II, prospective intervention trial was conducted to explore individualized nutrition management in UCBT patients.

Inclusion Criteria:

• Age 18-65 years old, conscious, with language communication skills;
• UCBT patients to be performed;
• Major organs without serious dysfunction;
• The participants agreed to participate in the study and signed the informed consent form.

Exclusion Criteria:

• Age < 18 years old or > 65 years old or with cognitive impairment can not complete this survey;
• Failure or recurrence of transplantation;
• Combined with severe other organ system diseases (such as severe cardiac insufficiency, autoimmune disease, active infection, severe trauma) ;
• Patients who have difficulty collecting data to complete the nutritional intervention;
• Patients who asked to withdraw from the study.