The goal of this clinical trial is to determine if Peer Empowered Endometriosis Pain Support (PEEPS), an 8-week interdisciplinary, integrative group care program, decreases pain interference in participants with endometriosis-associated chronic pelvic pain between the ages 18 and 48. The main question we aim to answer is:

Is PEEPS more effective than Education in decreasing pain interference?

Researchers will compare people receiving PEEPS plus usual care to those receiving Education plus usual care to see if people participating in PEEPS demonstrate improvements in pain, physical function, and quality of life.

Participants will:

• Complete baseline quality of life surveys
• Participate in an 8-session group care program
• Provide feedback on each session and the program globally
• Complete follow up quality of life surveys at PEEPS completion, 6- and 12-months post-completion.
• A sub-set will complete semi-structured interviews or focus groups about the experience of participating in PEEPS

Inclusion Criteria:

• Age 18-48 years
• Operative confirmation of endometriosis
• Chronic pelvic pain (pain perceived to originate from the pelvis, not exclusively during menses, lasting ≥6 months)
• No plan to have surgery before or during the PEEPS cohort
• Able to attend at least six of the eight 2-hour weekly sessions on the Washington University campus
• Comfort reading and speaking English as groups and materials are in English

Exclusion Criteria:

• Currently pregnant
• Severe physical impairment (limiting yoga participation)
• History of hip or spine surgery given increased risk of harm and need for extensive activity modification
• Current or history of psychiatric disorder with psychosis in order to minimize risk of adverse mental health effects to participants
• Opioid use ≥ 5 days in the past 3 months, other than for the 6-week post-operative period
• History of surgical removal of bilateral ovaries

Data will be preserved and shared through Digital Commons@Becker, an institutional repository administered and maintained by the Bernard Becker Medical Library at Washington University in St. Louis. All de-identified clinical, survey, and interview data from this project will be shared via Digital Commons@Becker of sufficient quality to validate and replicate research findings. Data dictionaries and study protocols will also be shared via Digital Commons@Becker.

All scientific data generated from this project will be made available no later than the time of an associated publication or 12 months after completion of the final data point, whichever is sooner.

The human subjects' data shared will be within the Institutional Review Board (IRB) bounds. The human subject data will be de-identified and made available via controlled access to the approved user(s) who signed the Data Use Agreement (DUA) to ensure the requester(s) have a legitimate reason for access, and agree not to attempt re-identification of participants and not to distribute data to unauthorized users.