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The aim of this project is to investigate the effect of triple prehabilitation led by nutritional optimization in liver cancer patients' surgery. It improves the preoperative nutritional status of cancer patients, reduces the incidence of early postoperative complications, promotes postoperative recovery, and improves the quality of patients' survival. Patients were randomized into experimental and control groups based on exclusion and inclusion criteria. Nutritional interventions and exercise and psychological interventions for patients. Interventions will continue for two weeks prior to surgery. Routine clinical blood tests will be performed at the time of enrollment, on the first day before surgery and on the first, third and fifth days after surgery. Enrolled patients were followed up by telephone or outpatient clinic at 1,3,6 months postoperatively.
Study subgroups: experimental group (nutritional optimization-led triple prehabilitation), control group (conventional triple prerehabilitation)
Enrollment Criteria
â‘ Patients diagnosed with primary liver cancer.
Patients between 18 and 70 years old.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nutritional optimization-led triple prehabilitation Intervention | Experimental | Nutritional optimization-led triple prehabilitation |
|
| Conventional triple prehabilitation Intervention | Other | Conventional triple prehabilitation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nutritional optimization-led triple prehabilitation Intervention | Other | The nutritional status of the patients was assessed together with the clinical nutritionist to develop an individualized nutritional plan. The experimental group used ordinary dietary supplementation + transoral nutritional supplementation, and the control group used ordinary dietary supplementation. The target energy was basal energy metabolism level * physical activity level, physical activity level was male: 1.55 female: 1.56; basal energy level was basal metabolism standardized value * body weight (basal metabolism standardized value for obese patients was 25; basal metabolism standardized value for normal or emaciated patients was 30). Add 600kcal capacity supplement to this. Exercise workouts focused on increasing lung capacity and cardiorespiratory tolerance. Specialized psychological interventions. |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative serum prealbumin | peripheral blood | One day after surgery, three days after surgery, five days after surgery |
| Postoperative transferrin | peripheral blood | One day after surgery, three days after surgery, five days after surgery |
| Postoperative retinol-binding protein | peripheral blood | One day after surgery, three days after surgery, five days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Six-minute walk test (6MWT) | walk test for six minutes | One week after surgery |
| grading and incidence of various types of complications | complications grade and incidence |
| Measure | Description | Time Frame |
|---|---|---|
| Drainage tube removal time | remove abdominal drainage | Postoperative, an average of 3 days |
Inclusion Criteria:
Patients diagnosed with primary liver cancer.
Patients between the ages of 18 and 70.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yuan Ding | Contact | +86 18858101960 | dingyuan@zju.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Yuan Ding | Second Affiliated Hospital, School of Medicine, Zhejiang University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China | Recruiting | Hangzhou | Zhejiang | 310009 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37431632 | Background | Lin Y, Zheng L, Fang K, Zheng Y, Wu J, Zheng M. Proportion of liver cancer cases and deaths attributable to potentially modifiable risk factors in China. Int J Epidemiol. 2023 Dec 25;52(6):1805-1814. doi: 10.1093/ije/dyad100. | |
| 26466573 | Background | Zhou YM, Zhang XF, Li B, Sui CJ, Yang JM. Postoperative complications affect early recurrence of hepatocellular carcinoma after curative resection. BMC Cancer. 2015 Oct 14;15:689. doi: 10.1186/s12885-015-1720-0. |
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|
| Conventional triple prehabilitation Intervention | Other | Conventional triple prehabilitation: ordinary dietary supplementation; exercise workouts focused on increasing lung capacity and cardiorespiratory tolerance; specialized psychological interventions. |
|
| one month after surgery |
| postoperative length of stay | stay hospital time | stay hospital time, an average of 10 days |
| 30-day readmission rate | readmission rate | postoperative for 30 days |
| patient long-term quality of life indicators (6 months) | life quality | during postoperative for 6 month |
| 31900738 | Background | Noba L, Rodgers S, Chandler C, Balfour A, Hariharan D, Yip VS. Enhanced Recovery After Surgery (ERAS) Reduces Hospital Costs and Improve Clinical Outcomes in Liver Surgery: a Systematic Review and Meta-Analysis. J Gastrointest Surg. 2020 Apr;24(4):918-932. doi: 10.1007/s11605-019-04499-0. Epub 2020 Jan 3. |
| 27780772 | Background | Forsmo HM, Pfeffer F, Rasdal A, Sintonen H, Korner H, Erichsen C. Pre- and postoperative stoma education and guidance within an enhanced recovery after surgery (ERAS) programme reduces length of hospital stay in colorectal surgery. Int J Surg. 2016 Dec;36(Pt A):121-126. doi: 10.1016/j.ijsu.2016.10.031. Epub 2016 Oct 22. |
| 35194410 | Background | Davis JF, van Rooijen SJ, Grimmett C, West MA, Campbell AM, Awasthi R, Slooter GD, Grocott MP, Carli F, Jack S. From Theory to Practice: An International Approach to Establishing Prehabilitation Programmes. Curr Anesthesiol Rep. 2022;12(1):129-137. doi: 10.1007/s40140-022-00516-2. Epub 2022 Feb 18. |
| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |
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