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This trial is conducted in China. This study is a randomized, single-center, open, three-period crossover trial in healthy subjects to compare the PK, PD, and safety of a single administration of GZR4 at different injection sites (abdomen, deltoid region of upper arm, and thigh).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GZR4 Injection- Abdomen | Experimental | Participants received GZR4 Injection by subcutaneous injection on Abdomen. |
|
| GZR4 Injection- Upper Arm | Experimental | Participants received GZR4 Injection by subcutaneous injection on Upper Arm. |
|
| GZR4 Injection- Thigh | Experimental | Participants received GZR4 Injection by subcutaneous injection on Thigh. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GZR4 Injection | Drug | GZR4 Injection administered sc, once weekly. |
|
| Measure | Description | Time Frame |
|---|---|---|
| AUC0-672h | Area Under the Concentration Versus Time Curve of GZR4 Injection From Time Zero to 672 hours | From Predose to 672 hours after a single dose |
| Measure | Description | Time Frame |
|---|---|---|
| AUC0-∞ | Area Under the Concentration Versus Time Curve of GZR4 Injection From Time Zero to Infinity | From Predose to 672 hours after a single dose |
| Cmax | Maximum Concentration of GZR4 Injection |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| wei zhao, PhD | Contact | 01056456746 | wei.zhao@ganlee.com |
| Name | Affiliation | Role |
|---|---|---|
| Clinical Transparency | Gan & Lee Pharmaceuticals. | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Study Site | Recruiting | Beijing | China |
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| From Predose to 672 hours after a single dose |