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Studies have shown that personalized nutrition advice is more effective compared to generic nutrition advice for weight loss purposes. However, since decentralization of clinical trials is on the rise, it of interest to test whether personalized nutrition advice is as effective when provided fully digitally. In the current study the investigators compare the effects of generic vs. personal nutritional interventions in a fully digital study. Three groups are included, a control group receiving generic nutritional advice, an intervention group receiving personalized nutrition advice and an intervention plus group receiving personalized nutrition advice plus personalized meals. The trial takes six weeks. Anthropometric data are collected every two weeks and data on changes in nutritional diet are collected at the beginning and end of the intervention. In addition, the opinion of the participants on trial participation is asked as well every two weeks during the trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | No Intervention | ||
| Intervention group | Experimental |
| |
| Intervention plus group | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Personalized nutritional advice | Other | Participants in the intervention group received personalized nutrition advice based on their dietary habits, weight, anthropometric data and physical activity. |
| Measure | Description | Time Frame |
|---|---|---|
| Body weight in kilograms | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Body height in meters | 6 weeks | |
| BMI as calculated by combining body weight and height (kg/m^2) | 6 weeks | |
| Hip circumference in centimeters |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Femke Hoevenaars, PhD | TNO | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| TNO | Leiden | South Holland | 2333BE | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41490780 | Derived | de Jong JC, Hoevenaars FP, Peters LG, Berendsen CM, Pasman WJ, Caspers MP, Dulos R, Wopereis S. A Real-Life Digital Intervention for Personalized Nutrition in Adults With Overweight or Obesity: Remote Randomized Controlled Trial. J Med Internet Res. 2026 Jan 5;28:e73367. doi: 10.2196/73367. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Personalized nutritional advice and food boxes | Other | Participants in the intervention plus group received the personalized nutrition advice while also receiving food boxes which are composed based on the personalized nutritional advice. |
|
| 6 weeks |
| Waist circumference in centimeters | 6 weeks |
| Neck circumference in centimeters | 6 weeks |
| Wrist circumference in centimeters | 6 weeks |
| Dietary habits as measured using the Nutri+ Module | Nutri+ Module is a food frequency questionnaire developed by TNO (TNO, Leiden, The Netherlands). This is used to obtain information on the habitual total food intake by asking food category consumption over the day. | 6 weeks |
| Opinion on digital intervention as measured using an online questionnaire. | The online questionnaire contained the following questions and multiple choice answers:
| 6 weeks |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |