1% Lidocaine Paracervical Block for Endometrial Biopsy

A Double-blind Randomized Controlled Trial of 1% Lidocaine Paracervical Block for Endometrial Biopsy

The objective of this study is to to determine whether 1% lidocaine paracervical block reduces pain during endometrial biopsy in comparison to no intervention.

The proposed study is a double-blind randomized controlled trial (RCT).

Each participant will be randomly assigned to one of two arms:

1. intervention (paracervical block - 10 mL 1% lidocaine with epinephrine)
2. control (gently tapping the cervicovaginal junction with a capped needle)

The primary outcome will be a global pain score, which will be patient-reported by the 100 mm Visual Analogue Scale (VAS) following the procedure.

Inclusion Criteria

• Any participant > or = age 18 years old presenting for an endometrial biopsy
• All parities of patients are eligible
• English speaking participants only

Exclusion Criteria

• Use of pain medication that is not an NSAID or acetaminophen (e.g. opioids, benzos) within past 24 hours
• Confirmed pregnancy
• Any diagnosed chronic pain syndromes (eg. fibromyalgia, vaginismus, interstitial cystitis)
• Contraindication to lidocaine
• Misoprostol administration within 24 hours
• Previous unsuccessful office attempt at endometrial biopsy by the same practitioner (note of clarification: previous unsuccessful biopsy attempt by a different practitioner will still be eligible)