This study intends to assess the possible effectiveness and safety of Diosmin and Hesperidin combination in patients with Helicobacter pylori Infection through evaluating its effect on stool antigen test and serum levels of inflammatory biomarkers as(TNF-A and MDA).

Inclusion Criteria:

• Confirmed H. pylori infection through stool antigen test.

  • Patients did not receive prior eradication therapy.
  • Male and female.
  • Age of 18-75 years old.
  • Good mental well-being to clearly understand the study's objectives, advantages and procedures.

Exclusion Criteria:

• Age less than 18 years.

  • Patients with previous H. pylori eradication therapy.
  • Patients with hypersensitivity/allergy to the study medications.
  • Patients with history of using proton pump inhibitor, H2-blocker, antibiotics that affect H.

pylori in the last month.

• Patients with history of using diosmin and/or hesperidin in the last month.
• Patients with history of gastric tumor or gastrointestinal (GI) surgery.
• Patients with concomitant severe disorders; cardiovascular, pulmonary, renal or hepatic, or active malignancy.
• Pregnancy or breastfeeding.
• History of drug misuse or recent alcohol consumption.
• Patients with gall bladder disorders.
• Patients on blood thinning agents (warfarin, clopidogril, aspirin, etc), anticonvulsants (carbamazepine and phenytoin), muscle relaxants (chlorzoxazone) and NSAID (diclofenac) in order to avoid potential pharmacodynamic and pharmacokinetic drug interactions with diosmin.
• Patients on anti-inflammatory drugs and antioxidant drugs.
• Patients with inflammatory conditions (ulcerative colitis, rheumatoid arthritis, etc.).
• Patients with conditions associated with oxidative stress (smoking, COPD, etc.).

Data will be supplied upon a reasonable request