Thrombectomy alone.

The modified Rankin Scale (mRS) is a 7-point ordinal scale ranging from 0 (no disability) to 6 (death). Higher scores indicate worse outcomes. The distribution of mRS scores (0-6) will be compared between treatment groups.

The modified Rankin Scale (mRS) is a 7-point ordinal scale ranging from 0 (no disability) to 6 (death). Higher scores indicate worse outcomes. The proportion of mRS 0-1 will be compared between treatment groups.

The modified Rankin Scale (mRS) is a 7-point ordinal scale ranging from 0 (no disability) to 6 (death). Higher scores indicate worse outcomes. The proportion of mRS 0-2 will be compared between treatment groups.

The National Institutes of Health Stroke Scale (NIHSS) is a 42-point ordinal scale ranging from 0 (no stroke symptoms) to 42 (severe stroke). Higher scores indicate worse neurological deficits. Early neurological improvement is defined as a reduction in NIHSS score by ≥8 points.

The National Institutes of Health Stroke Scale (NIHSS) is a 42-point ordinal scale ranging from 0 (no stroke symptoms) to 42 (severe stroke). Higher scores indicate worse neurological deficits. NIHSS scores will be serially assessed at specified intervals.

Protein and metabolite abundances will be normalized and compared between study groups to identify differentially expressed molecules and biological pathways associated with treatment response.

Higher percentages indicate increased platelet-neutrophil interactions and enhanced thrombo-inflammatory activity.

Higher percentages indicate increased platelet activation and prothrombotic potential.

Higher percentages indicate greater neutrophil activation and inflammatory response.

Quantitative assessment of clot initiation dynamics using TEG. R time measures the latency to initial fibrin formation (reported in seconds). Lower values indicate faster clot initiation, while higher values suggest delayed clotting.

Quantitative assessment of clot formation speed using TEG. K time reflects the time from clot initiation to a fixed clot strength (reported in seconds). Lower values indicate faster clot kinetics, while higher values suggest slower clot formation.

Quantitative assessment of fibrin polymerization rate using TEG. The alpha angle (reported in degrees) represents the slope of clot strengthening. Higher values indicate faster fibrin cross-linking and clot stability.

Quantitative assessment of clot strength using TEG. MA (reported in millimeters) measures the maximum clot firmness. Higher values indicate stronger clot structure, while lower values suggest weaker clot integrity.

Quantitative assessment of clot lysis potential using TEG. EPL (reported as a percentage) estimates the percentage of clot lysed after maximum amplitude is reached. Higher values indicate greater fibrinolysis activity.

Quantitative assessment of late-stage clot lysis using TEG. LY30 measures the percentage of clot lysed 30 minutes after maximum amplitude. Higher values indicate increased fibrinolysis over time.