Aim of the study is to perform a non-invasive multimodal retinal imaging investigation in a cohort of patients affected by USH2A retinitis pigmentosa (USH2A-RP), in order to develop a new diagnostic paradigm to categorize clinically relevant subgroups. All the procedures will be performed according to normal clinical practice. In addition, a novel quantitative profiling of serum microRNAs will be carried out in order to analyze the clinical importance of microRNA biomarkers in the clinical setting of the disease.

Inclusion Criteria:

• age >18 years
• genetically confirmed diagnosis of USH2A-RP
• availability of genetic tests to assess the pathogenic variants

Exclusion Criteria:

• inability to understand and sign the written informed consent form
• any inflammatory, infectious or degenerative eye disease
• media opacities resulting incompatible with good imaging quality
• uncontrolled systemic, metabolic, autoimmune neuroinflammatory and neurodegenerative disease
• ophthalmologic surgery within the previous six months

• 60 patients affected by genetically-confirmed USH2A-RP, both males and females, age >18 years
• 10 healthy age- and gender- matched control subjects recruited among healthy patients undergoing general ophthalmological examinations in the outpatient departments