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The development of AKI (Acute Kidney Injury) after cardiac arrest is a common factor associated with mortality. In this study, we aimed to evaluate the factors that increase the risk of developing AKI after cardiac arrest.
For the study, patients were evaluated for the incidence of acute kidney injury (AKI), factors that increase the risk of AKI, and the impact of AKI on mortality. In this process, demographic data, comorbidities, hemodynamic data, laboratory data, clinical symptoms and findings recorded in the electronic decision support system were recorded and analyzed.
This retrospective study was performed on patients hospitalized in intensive care units after cardiac arrest between 2013 and 2022. Patients who met the inclusion criteria were included in the study. Urea, creatinine values, and whether AKI was diagnosed or not were obtained from the data registry system. Statistical evaluation was performed using univariate binary logistic regression analysis.
Demographic data, location of cardiac arrest (in-hospital, out-of-hospital), and duration of CPR were recorded. In addition, the causes of cardiac arrest, HR/MAP (heart rate/average arterial pressure) ratio, and whether VSP (vasopressor) or INO (inotropic) medication was needed were recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AKI Group | AKI 1-3 in the first 48 hours after cardiac arrest according to KDIGO 2012 criteria | ||
| Non-AKI Group | Those who did not develop AKI in the first 48 hours after cardiac arrest according to KDIGO 2012 criteria |
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| Measure | Description | Time Frame |
|---|---|---|
| Acute Kidney Injury (AKI) | Creatinine values in the first 48 hours of intensive care unit admission after cardiac arrest | Within 48 hours after intensive care unit admission |
| Measure | Description | Time Frame |
|---|---|---|
| AKI incidence | Determination of the incidence of AKI development after cardiac arrest | Within 48 hours after intensive care unit admission |
| Mortality | Impact of AKI development on mortality in the early post-cardiac arrest period |
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Inclusion Criteria:
Exclusion Criteria:
Deaths in the first 48 hours
Missing data
End stage CKD or first day hemadsorption
CPR time <3 min
Unwitnessed cardiac arrest
Terminal malignancy
Having a pace marker
Massive bleeding
ECMO application
First day diyabetes insipitus
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Patients admitted to the Anesthesiology and Reanimation intensive care unit of Bakırköy Dr. Sadi Konuk Training and Research Hospital after cardiac arrest
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| Name | Affiliation | Role |
|---|---|---|
| MURAT ASLAN, Dr | Istanbul Bakırköy Dr Sadi Konuk Training and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bakırköy Dr. Sadi Konuk Training and Research Hospital | Istanbul | 34140 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33765189 | Background | Nolan JP, Sandroni C, Bottiger BW, Cariou A, Cronberg T, Friberg H, Genbrugge C, Haywood K, Lilja G, Moulaert VRM, Nikolaou N, Olasveengen TM, Skrifvars MB, Taccone F, Soar J. European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care. Intensive Care Med. 2021 Apr;47(4):369-421. doi: 10.1007/s00134-021-06368-4. Epub 2021 Mar 25. | |
| 28135002 |
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Data available from the publication date can start If requested, data will be shared with medical doctors dealing with
to be determined later
to be determined later
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| D006323 | Heart Arrest |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| Clinical and laboratory data within 48 hours after intensive care unit admission will be used |
| Background |
| Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Ischemia/Reperfusion. Compr Physiol. 2016 Dec 6;7(1):113-170. doi: 10.1002/cphy.c160006. |
| 23942856 | Background | Lemiale V, Dumas F, Mongardon N, Giovanetti O, Charpentier J, Chiche JD, Carli P, Mira JP, Nolan J, Cariou A. Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort. Intensive Care Med. 2013 Nov;39(11):1972-80. doi: 10.1007/s00134-013-3043-4. Epub 2013 Aug 14. |
| 22750662 | Background | Adler C, Reuter H, Seck C, Hellmich M, Zobel C. Fluid therapy and acute kidney injury in cardiogenic shock after cardiac arrest. Resuscitation. 2013 Feb;84(2):194-9. doi: 10.1016/j.resuscitation.2012.06.013. Epub 2012 Jun 30. |
| 34315321 | Background | Patyna S, Riekert K, Buettner S, Wagner A, Volk J, Weiler H, Erath-Honold JW, Geiger H, Fichtlscherer S, Honold J. Acute kidney injury after in-hospital cardiac arrest in a predominant internal medicine and cardiology patient population: incidence, risk factors, and impact on survival. Ren Fail. 2021 Dec;43(1):1163-1169. doi: 10.1080/0886022X.2021.1956538. |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |