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The research aimed to evaluate the impact of a successful Percutaneous coronary intervention of chronic total occlusions (CTO-PCI) on long-term MACE (Major Cardiovascular Events), symptoms, survival, Left Ventricular Ejection Fraction (LVEF) and myocardial ischemia up-to-8-years follow-up.
With this observational and prospective study, this research aimed to evaluate the impact of a successful CTO-PCI on long-term MACE (Major Cardiovascular Events), symptoms, survival, LVEF and myocardial ischemia up-to-8-years follow-up.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Successful CTO-PCI | Success was defined as a procedure achieving a final residual stenosis < 30% (by visual estimation) and a TIMI flow grade 3 after CTO recanalization in all living patients within 24h following angioplasty. |
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| Failed CTO-PCI | Success was defined as a procedure achieving a final residual stenosis < 30% (by visual estimation) and a TIMI flow grade 3 after CTO recanalization in all living patients within 24h following angioplasty. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Percutaneous Coronary Intervention of CTO | Other | CTO-PCI is a procedure of interventional cardiology attempting revascularisation of the CTO |
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| Measure | Description | Time Frame |
|---|---|---|
| Major cardiovascular events (MACE) | Incidence of composite of cardiac death, non-fatal myocardial infarction and new target vessel revascularization | Up to 8 years |
| Measure | Description | Time Frame |
|---|---|---|
| Non combined MACE components | Incidence of Cardiac death, non-fatal myocardial infarction and new target vessel revascularization | Up to 8 years |
| In-hospital events | Incidence of Procedural complications including death, periprocedural MI, coronary perforation, pericardial tamponade requiring drainage, local vascular complications, major bleeding, contrast induced nephropathy, stroke |
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Inclusion Criteria:
Exclusion Criteria:
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All patients who underwent an attempt of percutaneous recanalization of a CTO at Montpellier University Hospital between January 2015 and December 2022. All patients had symptoms (angina or dyspnea) and/or reversible myocardial ischemia in the territory of the occluded artery and myocardial viability
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| Name | Affiliation | Role |
|---|---|---|
| Florence Leclercq, PU-PH | University Hospital, Montpellier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Montpellier | 34090 | France |
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| Up to one week |
| Restenosis | Incidence of Restenosis Defined as a greater than 50% diameter stenosis at follow-up angiogram of the first dilated total occlusion. Reocclusion was defined as recurrent total occlusion of the first dilated total occlusion. | Up to 8 years |
| Ischemic burden | Comparison between pre and post-CTO ischemic tests | Up to 8 years |
| Stent thrombosis | Incidence of stent thrombosis defined as any myocardial infarction with angiographic confirmation of in-stent thrombus or unexplained death | Within 30 days after the procedure |
| LVEF | Percentage of Increase or decrease in LVEF after the CTO procedure compared with baseline LVEF | Up to 8 years |