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This study aims to investigate the incidence and prevalence of metabolic syndrome and metabolism-related diseases among healthcare workers, identify potential risk factors for these diseases, evaluate the control status of these conditions, and explore the significance of annual regular check-ups in improving metabolic-related health outcomes. All data for the study subjects are sourced from anonymized continuous records in hospital physical examinations and medical case files. The study does not involve any interventions. Upon obtaining the study data, researchers will use retrospective analysis methods to identify possible associations between risk factors and diseases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| the Metabolic Related Diseases in Medical Workers (MRDMW) cohort | The cohort includes all hospital employees who receive annual check-ups. |
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| Measure | Description | Time Frame |
|---|---|---|
| composite endpoint of cardiovascular and cerebrovascular diseases | The number of hospitalizations due to severe coronary heart disease, stroke, or sudden cardiac death. The outcome is determined if any of the first three discharge diagnoses include acute myocardial infarction, stroke, or sudden cardiac death, or if an emergency coronary stent placement or coronary artery bypass graft surgery is performed during hospitalization. | through study completion, an average of 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| new-onset metabolic syndrome | The number of individuals who did not meet the criteria for metabolic syndrome at the first examination but developed the syndrome later. The diagnostic criteria for metabolic syndrome involve meeting three or more of the following conditions: Abdominal obesity: waist circumference ≥90 (men) or ≥85 (women) cm. Hyperglycemia: fasting blood glucose ≥6.1 or 2-hour postprandial blood glucose ≥7.8 mmol/L or previously diagnosed diabetes. Hypertension: blood pressure ≥130/85 mmHg or previously diagnosed hypertension. Elevated triglycerides: fasting triglycerides ≥1.70 mmol/L or on lipid-lowering medication. Low fasting high-density lipoprotein cholesterol (HDL-C) <1.04 mmol/L. If waist circumference and HDL-C data are missing, abdominal obesity will be defined using the body mass index (BMI), calculated by dividing weight in kilograms by the square of height in meters (BMI ≥ 28.0 kg/m^2). Total cholesterol ≥ 5.17 mmol/L will be used as a substitute for the HDL-C indicator. |
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Inclusion Criteria:
Exclusion Criteria:
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Healthcare workers who were working in the hospital, including those who have retired from the hospital
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| Name | Affiliation | Role |
|---|---|---|
| Tengda Xu | Department of Health, Peking Union Medical College Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tengda Xu | Beijing | Beijing Municipality | 100730 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36162483 | Result | Strauss M, Lavie CJ, Lippi G, Brzek A, Vollenberg R, Sanchis-Gomar F, Leischik R. A systematic review of prevalence of metabolic syndrome in occupational groups - Does occupation matter in the global epidemic of metabolic syndrome? Prog Cardiovasc Dis. 2022 Nov-Dec;75:69-77. doi: 10.1016/j.pcad.2022.09.003. Epub 2022 Sep 23. | |
| 35919823 |
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Individual patient data (IPD) could be shared with other researchers after the publication of the study. However, the sharing should be permitted by the principal investigator from email. We do not have a web address for finding more information about the individual patient data (IPD) sharing plan. And we reject any data requests with commercial intentions.
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D003924 | Diabetes Mellitus, Type 2 |
| D006973 | Hypertension |
| D006949 | Hyperlipidemias |
| D009765 | Obesity |
| D002318 | Cardiovascular Diseases |
| D020521 | Stroke |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| through study completion, an average of 5 years |
| Liu J, Liu Q, Li Z, Du J, Wang C, Gao Y, Wei Z, Wang J, Shi Y, Su J, Liu Y, Wang P, Xie C, Li G, Shao B, Zhang L. Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults: Results from a Population-Based Study - Beijing, China, 2017-2018. China CDC Wkly. 2022 Jul 22;4(29):640-645. doi: 10.46234/ccdcw2022.138. |
| 24103567 | Result | Xi B, He D, Hu Y, Zhou D. Prevalence of metabolic syndrome and its influencing factors among the Chinese adults: the China Health and Nutrition Survey in 2009. Prev Med. 2013 Dec;57(6):867-71. doi: 10.1016/j.ypmed.2013.09.023. Epub 2013 Oct 5. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |
| D014652 | Vascular Diseases |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |