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| ID | Type | Description | Link |
|---|---|---|---|
| MR/X030539/1 | Other Grant/Funding Number | Medical Research Council | |
| 341570 | Other Identifier | Health Research Authority |
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| Name | Class |
|---|---|
| South London and Maudsley NHS Foundation Trust | OTHER |
| Imperial College London | OTHER |
| University College, London | OTHER |
| Oxford Health NHS Foundation Trust |
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UK Eating Disorder services are facing unprecedented demand, with effective service delivery hampered by inadequate resources, fragmented services and variable care pathways. Individuals with eating disorders, families and clinicians all agree on the critical need to improve care pathways and treatment, leading to better outcomes.
Eating disorders are serious, complex conditions influenced by a blend of biological, psychological, and environmental factors. The approach of this project is grounded in the "biopsychosocial" model. Recently, anorexia research confirms a genetic component, with biological, metabolic, and psychological mechanisms at play. Further biological research across eating disorders could allow a better understanding of the mechanisms underlying eating disorder development and better, more personalised treatments.
This project will test the feasibility of establishing a UK-wide NHS research network spanning child and adult eating disorder services to enable a step change in the ability to conduct eating disorder research. It will help address fragmentation and facilitate novel biological, psychological, and social research collaborations. The data the investigators gather will be open to all researchers for data analyses, and the collaborations established will form a collaborative network to enable future clinical trials, experimental medicine and psychology.
The study will be conducted at child and adult eating disorder services who opt to join the Network. Participants will be patients receiving treatment for an eating disorder at one of the participating services, and their parents/guardians if applicable.
Participants will complete questionnaires and have blood and other physical tests as specified in the EDCRN dataset. The study will last until 29th October 2026 (the end of the current funding period) and/or when a participant is discharged from treatment, whichever is sooner. For participants discharged before the study ends, there will be an opportunity for patients to complete optional follow-up questionnaires on a periodic basis.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EDCRN questionnaires | Other | Participants will complete questionnaires and have blood and other physical tests as specified in the EDCRN dataset. |
| Measure | Description | Time Frame |
|---|---|---|
| EDCRN dataset | The existence of a well-described dataset (maintained by at >50% eating disorder services across the UK) of eating disorder presentation, treatment, outcomes, demographics, social risk factors, and blood test results which can be accessed (with appropriate permissions) by researchers and others for the purposes of addressing novel research questions and facilitating service improvement efforts. The EDCRN dataset comprises the following parameters:
| 29th October 2026 |
| Measure | Description | Time Frame |
|---|---|---|
| Data on treatment effects | Data which provides insights into treatment moderators and mediators for different demographic groups. | 29th October 2026 |
| Genetic Biomarkers | Indicators of genetic biomarkers of treatment response. |
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Inclusion Criteria:
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Exclusion Criteria:
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The study population are individuals who are receiving treatment for an eating disorder(s) at a UK-based eating disorder service which is part of the EDCRN and (if desired by the patient and caregiver) their parents/guardians.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anna Carnegie | Contact | 020 7836 5454 | anna.carnegie@kcl.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Gerome Breen, PhD | King's College London (KCL) | Principal Investigator |
| Karina Allen, PhD | South London and Maudsley NHS Foundation Trust (SLaM) | Principal Investigator |
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| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |
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| OTHER_GOV |
| NHS Greater Glasgow and Clyde | OTHER |
| Birmingham Women's and Children's NHS Foundation Trust | OTHER |
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| 29th October 2026 |
| Socio-economic influences | Data which indicates socio-economic factors (e.g. the local food environment) influencing ED development, maintenance and outcomes. | 29th October 2026 |