Metabolic Adaptations to High-fat Diet | NCT06537401 | Trialant

Metabolic Adaptations to High-fat Diet | NCT06537401 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Hypercaloric, High Fat Diet	Experimental	For three calendar days participants will be asked to track all foods they eat and beverages they drink (habitual diet) in a mobile application. Following the three days following the habitual diet, participants will consume 165% of their estimated daily energy needs with 65% of those calories coming from fat.	Behavioral: Hypercaloric, High Fat Diet

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Hypercaloric, High Fat Diet	Behavioral	Participants will select meals from a list of sample breakfast, lunch, and dinner options from grocery stores. Typical intake will be estimated as 160-170% of resting metabolic rate, which will then be multiplied by 1.65 as the target calorie intake for the HFD. Target fat intake will be 65% of the HFD calorie target. To ensure participants will achieve the desired calorie and fat intake, they will also be provided with pre-made nutrient shakes and half-and-half. Participants will supplement their food intake with one to three shakes per day for each of the three days, depending on the fat and calorie content of the foods they select. They will be asked to add half-and-half equally between across the shakes.

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