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Examine the role of B-catenin in differentiation of cutaneous squamous cell carcinoma from other lesions that may be similar to it
Skin cancer is one of the most common form of cancer worldwide. Cutaneous squamous cell carcinoma is one of most common skin tumers that caused by many factors as ultra violet ,ionizing radiation and others . It was an advanced spectrum ranging from actinic keratosis to invasive and metastatic squmous cell carcinoma. Correct identification of cutaneous squamous cell carcinoma is a challenge as it has both clinically and histopathologically mimickers.
So the aim of this study is to identify the expression of B-catenin in cutaneous Squamous cell carcinoma and its mimickers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants | 50 formalin fixed parrafin embedded tissue blocks of cutaneous squamous cell carcinoma and its mimickers , from each block 2 tissue section; one tissue section stained by Hematoxilin and Eoisin and other tissue section will be stained immunohistochemically by anti human B-catenin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Immunohistochemical staining | Biological | Staining of cutanous squamous cell carcinoma and its mimickers by monoclonal antibodies against human B-catenin by immunohistochemical procedures |
| Measure | Description | Time Frame |
|---|---|---|
| Detection of B-catenin expression in cutanous squamous cell carcinoma and its mimickers | Detection of expression of B-catenin in cutaneous squamous cell carcinoma and its mimickers by immunohistochemical procedures using antihuman B-catenin monoclonal antibodies | 6 month |
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Inclusion Criteria:
Exclusion Criteria:
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archived formalin fixed parrafin embedded tissue pieces of patients of cutanous squamous cell carcinoma and its mimickers admitted to sohag University hospital from period juniory 2023 to June 2024
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nermeen S Habeeb, Doctor | Contact | 01200496394 | nermin.tharwat@med.sohag.edu.eg |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag University hospital | Recruiting | Sohag | Egypt |
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50 formalin fixed parrafin embedded