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Hepatectomy is a crucial surgical method for treating liver diseases such as liver cancer, hepatic hemangiomas, and biliary stones. Although hepatectomy has achieved significant therapeutic effects, postoperative complications remain an inevitable issue. Complications following hepatectomy include liver failure, hepatic vascular thrombosis, wound infection at the hepatic incision, and bile leakage, among others. These complications pose a serious threat to patients' health and life, and also increase the waste of medical resources and the cost of treatment. Currently, research on postoperative complications of hepatectomy mainly focuses on small sample studies from a single center, and most studies only focus on a specific complication, lacking comprehensive and systematic analysis. Therefore, it is necessary to conduct a retrospective study analysis of complications related to hepatectomy to more comprehensively and objectively understand the incidence, risk factors, prevention, and treatment of postoperative complications, providing clinical doctors with more scientific treatment plans and guidance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PHLF/NPHLF | PHLF:Post-hepatectomy liver failure,PHLF is commonly diagnosed and classified according to the criteria of the International Study Group for Liver Surgery (ISGLS), utilizing markers of liver function measured on or after postoperative day 5 (POD5). NPHLF:Patients who did not experience liver failure following hepatectomy. |
| |
| Liver Cirrhosis/No Liver Cirrhosis | Whether the patient has cirrhosis |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| International Study Group for Liver Surgery (ISGLS) | Diagnostic Test | According to the ISGLS criteria, the patient was judged to have liver failure and further analysis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Post-hepatectomy liver failure (PHLF) | PHLF is commonly diagnosed and classified according to the criteria of the International Study Group for Liver Surgery (ISGLS), utilizing markers of liver function measured on or after postoperative day 5 (POD5). | On and after the 5th postoperative day |
| Measure | Description | Time Frame |
|---|---|---|
| mortality | The patient died postoperatively | During 30 days after surgery |
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Inclusion Criteria:
Exclusion Criteria:
Exclusion criteria are as follows:
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Patients who underwent liver resection surgery at the participating centers
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kai Wang | Contact | 13710574386 | kaiwang@smu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanfang Hospital | Recruiting | Guangzhou | Guangdong | 510515 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40630620 | Derived | Wang K, Yang Q, Li K, Tang S, Zhang B, Liao X, Du S, Fu W, Li Z, Chen H, Xie H, Huang P, Li J, Wang Q, Liu H, Huang Z, Heng PA, Wan X, Li C, Si W. Learning-based early detection of post-hepatectomy liver failure using temporal perioperative data: a nationwide multicenter retrospective study in China. EClinicalMedicine. 2025 May 6;83:103220. doi: 10.1016/j.eclinm.2025.103220. eCollection 2025 May. |
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To ensure the protection of patients' clinical information data, ethical committee approval is required before sharing data with other research studies. This process is crucial for maintaining patient confidentiality and adhering to privacy regulations and ethical standards in research.
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| ID | Term |
|---|---|
| D017093 | Liver Failure |
| D008107 | Liver Diseases |
| ID | Term |
|---|---|
| D048550 | Hepatic Insufficiency |
| D004066 | Digestive System Diseases |
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