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The goal of this prospective cohort study is to investigate the contribution of stigma and discrimination due to body size to adverse pregnancy outcomes. We also aim to explore the role of psychological and social factors in this relationship. The specific objectives of this study are:
Objective 1: Explore weight stigma as a mediator of the association between BMI ≥30 kg/m2 and adverse pregnancy outcomes.
Objective 2: Explore confounding factors not previously considered such as weight cycling, trauma, eating disorders, and internalised weight bias as mediators in the relationship between obesity and adverse pregnancy outcomes.
The specific research questions for each objective are:
Objective 1 RQ1.1: Does weight stigma experienced during pregnancy in a healthcare setting reported up to 34 weeks gestation mediate the association between pre-pregnancy obesity (BMI ≥30) and gestational diabetes mellitis (GDM) (primary outcome)?
RQ1.2: Does weight stigma experienced during pregnancy in a healthcare setting reported up to 34 weeks gestation mediate the association between pre-pregnancy obesity (BMI ≥30) and (i) induction of labour; (iv) mode of birth; (ii) gestational hypertension (any); (iii) infant birth weight; and (iv) establishment of breastfeeding by 6 weeks postpartum (secondary outcomes)?
Objective 2:
RQ2.1: Do weight cycling, history of trauma, history of eating disorders, and internalised weight bias explain any of the variance in the mediation relationships described above?
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| Measure | Description | Time Frame |
|---|---|---|
| Proportion of women diagnosed with gestational diabetes mellitis by 34 weeks gestation | Measuring the number of women reporting a diagnosis of gestational diabetes mellitis by 34 weeks gestation as assessed via self-reported measures and chart review. | 34 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of women experiencing induction of labour | Identifying whether the woman's labour was spontaneous or induced measured via a self-reported questionnaire. | 6 weeks postpartum |
| Proportion of women reporting each mode of birth (i.e., vaginal birth, caesarean section, assisted vaginal birth, or other) |
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Inclusion Criteria:
Exclusion Criteria:
Women who are pregnant between 10-22 weeks gestation
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Participants will be pregnant women who are at least 18 years old with a singleton pregnancy, and who are booked in to give birth at Adelaide Women's and Children's Hospital or Royal Women's and Children's Brisbane. At baseline, women must be between 10 and 22 weeks' gestation.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Briony Hill, PhD | Contact | +61421012283 | briony.hill@monash.edu | |
| Megan Mitchell, PhD | Contact | megan.mitchell@adelaide.edu.au |
| Name | Affiliation | Role |
|---|---|---|
| Briony Hill, PhD | Monash University | Principal Investigator |
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| ID | Term |
|---|---|
| D000079322 | Weight Prejudice |
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D011287 | Prejudice |
| D012919 | Social Behavior |
| D001519 | Behavior |
| D044343 | Overnutrition |
| D009748 |
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Identifying the mode of birth assessed via a self-reported questionnaire. Options are: vaginal birth, caesarean section, assisted vaginal birth (e.g., with forceps), or other. |
| 6 weeks postpartum |
| Proportion of women who reported experiencing gestational hypertension in their most recent pregnancy | Identifying the proportion of women who reported a diagnosis of gestational hypertension during their most recent pregnancy via a self-reported questionnaire. | 6 weeks postpartum |
| Infant birth weight (in grams) reported by mothers for their most recent infant | Infant birth weight (in grams) reported by mothers based on their most recent baby's birth certificate or hospital discharge summary information. | 6 weeks postpartum |
| Proportion of women currently breastfeeding their infant reported by mothers at 6-weeks postpartum | The proportion of women currently breastfeeding their infant (yes/no) reported by mothers at 6-weeks postpartum | 6 weeks postpartum |
| Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |