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The goal of this observational study is to search for accurate diagnoses for patients with chronic diarrhea and assess the prevalence of microscopic colitis. The main question[s] it aims to answer [is/are]:
Does microscopic colitis account for a significant portion of patients with chronic diarrhea?
Participants will subjected to:
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| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants with Chronic Diarrhea Diagnosed with Microscopic Colitis | Diagnostic criteria for the diagnosis of microscopic colitis include increased chronic inflammatory infiltration in the lamina propria, increased intraepithelial lymphocytes (IELs), degeneration of surface epithelium, and increased mitosis in crypts. | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of Lymphocytic and Collagenous Types of Microscopic Colitis in Individuals Experiencing Chronic Diarrhea | Over 20 IELs per 100 inter-cryptal epithelial cells (normal <1-5/100) were required for the diagnosis of lymphocytic colitis. For collagenous colitis, subepithelial collagen band thickness was measured by ocular micrometer in specimens stained with Masson's Trichrome. Specimen thickness over 10 μm was required for the diagnosis. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients presented with chronic diarrhea in the outpatient clinic or the inward in the Gastroenterology and Hepatology unit in the Internal Medicine Department, Zagazig University hospitals from January 2024 to January 2025
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| Name | Affiliation | Role |
|---|---|---|
| Ayman Sadek, MD | Associate Professor of Internal Medicine - Zagazig University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zagazig University Hospital | Zagazig | Sharqia Province | 44519 | Egypt |
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| ID | Term |
|---|---|
| D046728 | Colitis, Microscopic |
| ID | Term |
|---|---|
| D003092 | Colitis |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| 2 weeks |
| D003108 |
| Colonic Diseases |
| D007410 | Intestinal Diseases |