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The optimal cut-off value for diagnosing hirsutism in the modified Ferriman-Gallwey (mFG) point scale in the Polish population is not known. The correlation of mFG with the severity of androgenetic alopecia in the Ludwig scale (LS) is not known.
The aim of the study is to determine the cut-off point for the diagnosis of hirsutism and to assess the correlation of the mFG scale score with the LS of androgenetic alopecia severity.
The aim of the study is to:
Inclusion criteria are as follows: i) oligoovulation, i.e. menstrual cycles every <21 days or >35 days, ii) age 18-45 years Exclusion criteria: none
To achieve the study objectives, the following will be performed:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Polycystic ovary syndrome (PCOS) | Women diagnosed with polycystic ovary syndrome based on International Evidence-based Guideline for the assessment and management of polycystic ovary syndrome (2023) |
| |
| Hypothalamic-pituitary-ovarian dysfunction (HPOD) | Women diagnosed with hypothalamic-pituitary-ovarian dysfunction based on The FIGO ovulatory disorders classification system (2022) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Assessment of the severity of hirsutism using the visual modified Ferriman-Gallwey scale | Diagnostic Test | Assessment of the severity of hirsutism using the visual modified Ferriman-Gallwey scale in 9 body regions rated from 0 (no growth of terminal hair) to 4 (extensive hair growth), thus with a score ranging from 0 (the lowest score - no hirsutism) to 36 points (the highest score - the greatest severity of hirsutism) |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of the severity of hirsutism in the PCOS and HPOD groups | Comparison of the mFG score in the PCOS and HPOD groups; The modified Ferriman-Gallwey (mFG) scale assesses the severity of excessive hair growth on a scale of 0-4 points in 9 body regions (Upper lip, Chin, Chest, Upper back, Lower back, Upper abdomen, Lower abdomen, Upper arms, Thighs); the lowest possible score is 0 and the highest is 36; the higher the score, the greater the severity of excess hair | up to 6 months |
| Comparison of the severity of endogenetic alopecia in the PCOS and HPOD groups | Comparison of the LS score in the PCOS and HPOD groups; The Ludwig Scale (LS) assesses the severity of androgenetic alopecia on a scale from I to III, with additional sub-points within some of the above grades, i.e. I-1, I-2, I-3, I-4, II-1, II-2, III, IV (frontal - advanced); the higher the grade, the greater the severity of alopecia | up to 6 months |
| Calculation of cut-off point for diagnosing hirsutism in the study population | The cut-off point for diagnosing hirsutism will be calculated using the receiver operating characteristic curve | up to 6 months |
| Assessment of diagnostic convergence of mFG and LS scales in diagnosing clinical hyperandrogenism | The correlation of mFG and LS scale scores in the study population will be assessed using standard statistical methods | up to 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Women diagnosed and treated at the University Hospital in Krakow due to normogonadotropic anovulation
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| Name | Affiliation | Role |
|---|---|---|
| Kazimierz PityĆski, Prof. | Jagiellonian University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jagiellonian University Medical College | Krakow | 31-501 | Poland |
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| ID | Term |
|---|---|
| D000858 | Anovulation |
| D006628 | Hirsutism |
| D000505 | Alopecia |
| ID | Term |
|---|---|
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
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|
| Assessment of the severity of endogenetic alopecia using the visual Ludwig Scale | Diagnostic Test | Visual assessment of baldness on the Ludwig scale from I (least severe baldness) to III (most severe baldness): Type I - minimal thinning of the mid-line parting in the hair; Type II - gradual thinning and noticeable widening of the mid-line parting in the hair; Type III - Heavy to total thinning of the mid-line |
|
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
| D006201 | Hair Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D014770 | Virilism |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007039 | Hypotrichosis |
| D020763 | Pathological Conditions, Anatomical |