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Acute watery diarrhea is defined as the passage of 3 or more loose or liquid stools per day for 3 or more days but less than 14 days, including patients with mild to moderate dehydration per WHO classification. The study's outcome variables are stool frequency, measured by the total number of stools passed during 24 and 48 hours from the initiation of treatment, and hospital duration, measured by the total duration of hospital stay in hours. The null hypothesis states that racecadotril combined with standard treatment has no effect on reducing the mean number of stools passed during 48 hours compared to standard treatment alone in pediatric patients with acute watery diarrhea, while the alternate hypothesis suggests that racecadotril combined with standard treatment will significantly reduce the mean number of stools passed during 48 hours compared to standard treatment alone in these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| treatment group receiving (racecadotril+ORS+Zinc) | Experimental | The intervention group will receive racecadotril+ORS+Zinc while the reference group will receive ORS+Zinc alone |
|
| the control group (receiving ORS + Zinc or standard treatment) | Active Comparator | The intervention group will receive racecadotril+ORS+Zinc while the reference group will receive ORS+Zinc alone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Racecadotril | Drug | The intervention group will receive racecadotril+ORS+Zinc |
|
| Measure | Description | Time Frame |
|---|---|---|
| Stool frequency | Total no. of stools passed during 24 and 48 hours from initiation of treatment will be compared between two groups | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Hospital Duration | Total duration of hospital stay taken in hours | 48 Hours |
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Inclusion Criteria:
Hospitalized Patients with acute watery diarrhea of both genders who are
Age: 03 months to 05 years
Present in first 24 hours of onset of disease.
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aqsa Jabeen Jabeen, MBBS | Contact | 03327148228 | aqsajabeen2010@gmail.com |
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| ID | Term |
|---|---|
| D003967 | Diarrhea |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C049331 | racecadotril |
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