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| ID | Type | Description | Link |
|---|---|---|---|
| R01MH135730 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
| National Institute of Mental Health (NIMH) | NIH |
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This project aims to develop a community of practice; then test a combination of community of practice, quality improvement, and a training toolkit, to enhance implementation and clinical outcomes; and identify patterns attributes associated with successful implementation.
Aim 1: To develop and determine the impact of a Community of Practice (CoP) on stakeholder and healthcare worker engagement and knowledge of integrated pre-exposure prophylaxis (PrEP) delivery.
Aim 2: To determine the impact of a 3-component scale-up package on implementation outcomes and PrEP patient outcomes among pregnant and postpartum populations.
Aim 2a: To determine the impact of the scale-up package on PrEP implementation outcomes, including reach, service penetration, adoption (primary outcomes), and PrEP fidelity and maintenance (secondary outcomes).
Aim 2b: To determine the impact of the scale-up package on PrEP patient outcomes, including PrEP initiation and continuation.
Aim 3: To identify difference-making bundles of facility- and regional-level attributes and implementation processes that influence reach, fidelity implementation, and maintenance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Implementation strategy package | Experimental | Package includes a Community of Practice, a quality improvement (QI) practice, and a training & delivery toolkit. |
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| Comparison | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Implementation strategy package | Other | Package includes a Community of Practice, a quality improvement (QI) practice, and a training & delivery toolkit. |
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| Measure | Description | Time Frame |
|---|---|---|
| Service penetration | Number and proportion of pregnant and postpartum maternal child health clinic (MCH) clients who are screened for PrEP | 1 year |
| Reach | Number of pregnant and postpartum MCH clients initiated on PrEP each month | 1 year |
| Adoption (provider) | Number, proportion, and representativeness of nurses and HIV testing services (HTS) providers who have begun offering or counseling on PrEP in MCH | 1 year |
| Adoption (facility) | Proportion of facilities per county that have begun offering PrEP in MCH | 1 year |
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Inclusion Criteria:
Health Care Workers:
Clients:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anjuli Wagner, PhD | University of Washington | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kapsabet County Referral Hospital | Kapsabet | Nandi | Kenya | |||
| Kitale County Referral Hospital |
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| ID | Term |
|---|---|
| D000163 | Acquired Immunodeficiency Syndrome |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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Difference in differences design, also known as a controlled pre-post design
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| Kitale |
| Trans Nzoia |
| Kenya |
| Uasin Gishu District Hospital | Eldoret | Uasin Gishu County | Kenya |
| Busia County Referral Hospital | Busia | Kenya |
| Kenyatta National Hospital | Nairobi | MRX5 + 53 | Kenya |
| D015229 |
| Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012897 | Slow Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |