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The influence of anesthesia on the course of multiple sclerosis is poorly investigated and the literature is limited.
The aim of this study is to investigate multiple sclerosis relapse after different types of anesthesia.
The influence of anesthesia on the course of multiple sclerosis is poorly investigated and the literature is limited. A possible relapse after neuraxial anesthesia, it is believed to be associated with local anesthetic's toxicity and concentration.
The aim of this study is to investigate multiple sclerosis relapse after different types of anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| General anaesthesia | Intravenous or volatile general anesthesia was preformed with different type of airway management (endotracheal tube, laryngeal mask and bag mask ventilation) |
| |
| Neuraxial anaesthesia | Neuraxial anesthesia was administered using spinal or epidural injections of local anesthetic with or without opioid. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| General anaesthesia | Procedure | Intravenous or volatile general anesthesia was preformed with different type of airway management (endotracheal tube, laryngeal mask and bag mask ventilation) |
| Measure | Description | Time Frame |
|---|---|---|
| Multiple sclerosis relapse after 1 month | Overall incidence of multiple sclerosis relapse after 1 month after anaesthesia | 1 month |
| Multiple sclerosis relapse after 3 months | Overall incidence of multiple sclerosis relapse after 3 months after anaesthesia | 3 months |
| Multiple sclerosis relapse after 6 months | Overall incidence of multiple sclerosis relapse after 6 months after anaesthesia | 6 months |
| Multiple sclerosis relapse after 12 months | Overall incidence of multiple sclerosis relapse after 12 months after anaesthesia | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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This study included adult patientswith multiple sclerosis diagnosis who had undergone general or neuraxial anesthesia in General Hospital Varaždin during the period from 01.01.2012 to 31.12.2022.
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| Name | Affiliation | Role |
|---|---|---|
| Monika Kocman Panic, MD | Varazdin General Hospital, Varazdin, Croatia | Principal Investigator |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D012008 | Recurrence |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| ID | Term |
|---|---|
| D000768 | Anesthesia, General |
| ID | Term |
|---|---|
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
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| Neuraxial anaesthesia | Procedure | spinal or epidural injections of local anesthetic with or without opioid |
|
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |