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This study aims to establish a prospective case registration research platform for electroacupuncture in treating behavioral and psychological symptoms in patients with mild to moderate Alzheimer's disease, and to investigate the dose-effect relationship and cost-effectiveness of electroacupuncture for these symptoms.
To establish a prospective case registration research platform aimed at treating mild to moderate Alzheimer's disease patients presenting with behavioral and psychological symptoms. This platform will document the electroacupuncture treatment process, conduct regular assessments using neuropsychiatric questionnaires (NPI) and the Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change Scale (ADAS-CGIC), and compare the effects of different parameters, treatment frequency, and duration of electroacupuncture on therapeutic outcomes for various behavioral and psychological symptoms in Alzheimer's disease patients. Furthermore, it aims to investigate the influencing factors of electroacupuncture treatment for behavioral and psychological symptoms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Affective symptom group | A group of Alzheimer's patients showing emotional symptoms such as anxiety, depression, apathy, etc. |
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| Psychotic symptom group | A group of Alzheimer's patients showing psychotic symptoms such as delusions, hallucinations, etc. |
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| Hyperactivity symptom group | A group of Alzheimer's patients showing hyperactivity symptoms such as irritability, aggression, aberrant motor behaviour, etc. |
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| Euphoric symptom group | A group of Alzheimer's patients showing euphpric symptoms. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Electroacupuncture treatment | Other | Electroacupuncture treatment consists of conventional acupuncture and electrical stimulation. After acupuncture, the electrical stimulation is continuously stimulated. |
| Measure | Description | Time Frame |
|---|---|---|
| Neuropsychiatric Inventory (NPI) | NPI is used to evaluate neuropsychiatric behavioral symptoms of dementia patients. The scale assesses the neuropsychiatric disorders of patients according to the caregiver's view of the patient's behavior and the corresponding distress felt by the patient. The scoring range of the patient evaluation scale is 0-144 points, and the scoring of the caregiver distress scale is 0-60 points, the lower the score is, the better the patient's condition is. | NPI will be performed before treatment and every month after treatment for up to 24 months |
| Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC) | ADCS-CGIC is a global rating of change developed to assess clinically significant change in symptoms over time in AD clinical trials. Clinicians rate patient symptoms on the ADCS-CGIC as: very much improved (1), much improved (2), minimally improved (3), no change (4), minimally worse (5), much worse (6), and very much worse (7) compared to baseline symptoms. | The ADCS-CGIC will be performed before treatment and every 2 month after treatment for up to 24 months |
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Inclusion Criteria:
Exclusion Criteria:
1.There are contraindications for acupuncture treatment, such as the tendency of acupoint bleeding or allergy to metal
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Alzheimer's disease patients with behavioral and psycological symptoms, such as apathy, depression, anxiety, delusions, hallucinations, irritability, etc.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Baohui B Jia | Contact | 010-88001454 | jiabaohui2504@gamyy.cn | |
| Ran Li | Contact | 18801094908 | lcgxliran@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Baohui Jia | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing United Family Rehabilitation Hospital | Beijing | Beijing Municipality | 100015 | China |
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| China-Japan Friendship Hospital | Beijing | Beijing Municipality | 100029 | China |
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| Guang'anmen Hospital of China Academy of Chinese Medical Sciences | Beijing | Beijing Municipality | 100053 | China |
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| Xuanwu Hospital of Capital Medical University | Beijing | Beijing Municipality | 100053 | China |
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| Beijing Geriatric Hospital | Beijing | Beijing Municipality | 100095 | China |
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| Fujian University of Traditional Chinese Medicine | Fuzhou | Fujian | 350122 | China |
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| The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine | Harbin | Heilongjiang | 150001 | China |
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| ID | Term |
|---|---|
| D001519 | Behavior |
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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