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While a theoretical increase in systolic blood pressure (BP) of 10 mmHg can triple the relative risk of cardiovascular disease (CVD), the potential presence of a white coat effect (WCE) can interfere with the assessment of blood pressure control in the consultation. However, it is often difficult to assess the presence of a white coat effect (a quantitative variable) in general practice because of the difficulties in performing ambulatory BP measurements (self-measurement of blood pressure or ambulatory BP measurements). We have therefore previously described a surrogate concept of WCE obtained during a consultation with a general practitioner. It corresponds to a reduction of 10mmHg or more in systolic BP between the start and the end of the consultation. We have named it 'office white coat effect tail' (OWCET) and we have shown that OWCET, as a dichotomous variable, in a large Italian population cohort, with a follow-up of more than 18 years, was associated with an excess incidence of stroke, myocardial infarction (MI) and CVD and with excess mortality from MI and CVD. This concept appears to be more prevalent in women and is independent of blood pressure variability (regression to the mean). In addition, there is a genuine correlation between WCE and OWCET. To our knowledge, the reproducibility of the OWCET has never been studied, which could distort the relevance of this concept in the context of cardiovascular risk stratification in primary care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| no reproducibility of OWCET | Other |
| |
| reproducibility of OWCET | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood pressure measurement | Device | automated blood pressure measurement on 3 occasions at each consultation, twice with one month apart |
|
| Measure | Description | Time Frame |
|---|---|---|
| OWCET | Measurement of OWCET on two occasions during two consultations separated by one month, using the same automated blood pressure monitor, in order to estimate an intraclass kappa coefficient (qualitative measurement). | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Factors associated with reproducibility of OWCET | Patients characteristics | 1 month |
| Different definitions of OWCET | Variation of OWCET definition in order to test OWCET reproducibility |
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Inclusion Criteria:
Exclusion Criteria:
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An initial inclusion visit, followed by a further visit at 1 month, with automated blood pressure measurement on 3 occasions at each visit, one month apart. At the first consultation, useful data were collected (age, sex, tobacco, alcohol, BMI, history of diabetes, history of chronic kidney disease, history of ischaemic heart disease).
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| ID | Term |
|---|---|
| D059466 | White Coat Hypertension |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D001795 | Blood Pressure Determination |
| ID | Term |
|---|---|
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D010808 | Physical Examination |
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cohort
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adults > 18 y
| 1 month |
| blood pressure Variability | To test impact of blood pressure variability | 1 month |