Effectiveness of CBT in Improving Psycho-Neuro-Endocrine Factors in Women Following In Vitro Fertilization Program

The Effectiveness of Cognitive Behavioral Therapy in Improving Psycho-Neuro-Endocrine Factors in Women Following In Vitro Fertilization Program

The goal of this clinical trial is to learn if Cognitive Behavioral Therapy (CBT) can improve psychological, neurological, and hormonal aspects in women undergoing In Vitro Fertilization (IVF). The main questions it aims to answer are:

• Is CBT effective in improving psychological aspects (anxiety, depression, and coping mechanism) in women undergoing IVF?
• Is CBT effective in improving neuroendocrine aspects (cortisol levels, neuroepinephrine levels, free trioodothyronine levels) in women underoing IVF?

Researchers will compare CBT to no intervention to see if CBT is effective in improving psychoneuroendocrine aspects.

Participants will

• attend 8 appointments once a week, during which they will be given CBT or no intervention
• have their anxiety score, depression score, and dominant coping mechanism assessed before the first appointment and during appointment 3, 6, and 8
• have their cortisol levels, norepinephrine levels, and free triiodothyronine levels assessed before the first appointment and during appointment 3, 6, and 8

Inclusion Criteria:

• Women with primary infertility
• Aged 25-42 at the start of the study
• Willing to participate in the study and willing to sign informed consent form
• Minimum education of high school, able to read, write and understand Bahasa Indonesia

Exclusion Criteria:

• Having one or multiple psychotic disorder(s)