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Total hip arthroplasty (THA) is a commonly used treatment for hip lesions, but it is often accompanied by persistent pain after surgery, which obviously affects the quality of life of patients, so perfect postoperative analgesia is particularly important for the rapid recovery of patients. Peripheral nerve blocks are often used as postoperative analgesia for THA, and fascia iliaca compartment block (FICB) is the preferred nerve block for THA due to its good postoperative analgesic effect and fewer postoperative adverse reactions. However, the effect of nerve block with ropivacaine alone is short, and the postoperative analgesia time is limited, which seriously affects the patient's surgical recovery. Therefore, prolonging the postoperative analgesic time is an urgent problem to be solved by FICB, and some scholars recommend the combined use of local anesthetic adjuvants to prolong the block time, which is an effective and safe method. In this study, a long-acting analgesic drug, methylene blue, was selected as an adjuvant for ropivacaine for FICB, but there was no unified clinical standard for the postoperative analgesic concentration of methylene blue.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dilute 0.25% ropivacaine + 20 mg methylene blue to 30 ml | Experimental |
| |
| 0.25% ropivacaine + 40 mg methylene blue diluted to 30 ml | Experimental |
| |
| 0.25% ropivacaine 30 ml | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ropivacaine combined with methylene blue for iliac fascia block | Drug | Ultrasound-guided fascia iliaca block using different concentrations of methylene blue combined with ropivacaine |
| Measure | Description | Time Frame |
|---|---|---|
| visual analogue scale(VAS) | Use a swimming ruler about 10 cm long, marked with 10 ticks on one side, and "0" and "10" at each end. A score of 0 indicates no pain, a score of 10 indicates the most severe pain that is unbearable, and the higher the score, the greater the degree of pain | The first, third, and seventh days after the surgery |
| Mini-Mental State Examination (MMSE) | An examination tool to assess cognitive status | Seventh day after surgery |
| Harris Hip Scoring System | Harris (1969) proposed a scoring system to evaluate the functional status and postoperative efficacy of patients with artificial hip arthroplasty | On the seventh day after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Number of postoperative salvage analgesia | From the end of the surgery to the seventh day after the surgery | |
| Walking distance for the first time getting out of bed | From the end of the surgery to the seventh day after the surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhang Yang | Taizhou | China |
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| Number of exercises to get out of bed within 7 days of surgery | From the end of the surgery to the seventh day after the surgery |
| ID | Term |
|---|---|
| D008751 | Methylene Blue |
| ID | Term |
|---|---|
| D010640 | Phenothiazines |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D006575 | Heterocyclic Compounds, 3-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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