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This is a multicentre prospective cohort study where patients will receive up to 14 days of continuous ECG monitoring by wearing a portable monitoring device, starting within 72 hours after noncardiac surgery.
POAF commonly occurs after noncardiac surgery and is associated with adverse long-term outcomes. Despite this, patients with POAF are routinely being missed during clinical practice. Continuous ECG monitoring has the potential to enhance POAF detection and improve clinical care in affected patients. Based on this background, the DETECT-POAF study will determine the incidence of clinically important POAF in those receiving up to 14 days of continuous ECG monitoring within 35 days after noncardiac surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study Cohort | Participants will receive up to 14 days of continuous cardiac monitoring |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac monitoring device | Device | Portable, up to 14 days of monitoring |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of clinically important post-operative atrial fibrillation/atrial flutter | The primary outcome is clinically important POAF, defined as:
| Within 35 days of non-cardiac surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of sustained ventricular arrhythmia | Within 35 days of non-cardiac surgery | |
| Incidence of sinus node dysfunction | Within 35 days of non-cardiac surgery | |
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Inclusion Criteria:
Had undergone noncardiac surgery within the past 72 hours and requiring, or expected to require, at least one of the following:
Have one of the following high-risk criteria;
Provide written informed consent to participate.
Exclusion Criteria:
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Adults who have undergone noncardiac surgery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Vitheya Thanabalan | Contact | +1 905-296-2710 | detectpoaf@phri.ca | |
| Kate Brady | Contact | detectpoaf@phri.ca |
| Name | Affiliation | Role |
|---|---|---|
| David Conen, MD, MPH | Population Health Research Institute | Principal Investigator |
| Michael K Wang, MD | Population Health Research Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hamilton General Hospital | Recruiting | Hamilton | Ontario | L8L 2X2 | Canada |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| D001282 | Atrial Flutter |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| Incidence of high-grade atrioventricular block |
| Within 35 days of non-cardiac surgery |
| Incidence of death | Within 35 days of non-cardiac surgery |
| Incidence of clinically important post-operative atrial fibrillation/atrial flutter | Within 14 days of continuous cardiac monitoring |
| Incidence of clinically important post-operative atrial fibrillation/atrial flutter detected by clinical monitoring only | Within 35 days of non-cardiac surgery |
| Incidence of clinically important post-operative atrial fibrillation/atrial flutter define with minimum duration of 6 minutes | Within 35 days of non-cardiac surgery |
| Incidence of clinically important post-operative atrial fibrillation/atrial flutter detected by study device monitoring only | Within 35 days of non-cardiac surgery |
| Proportion of participants meeting eligibility criteria for ASPIRE-AF study | Within 35 days of non-cardiac surgery |
| Multivariate odds ratio of risk factors associated with the occurrence of clinically important POAF | A multivariate logistic regression analysis of age, sex, surgical urgency, type of surgery, vascular disease, chronic kidney disease, and heart failure. | Within 35 days of non-cardiac surgery |
| St. Joseph's Healthcare Hamilton | Not yet recruiting | Hamilton | Ontario | L8N 4A6 | Canada |
|
| Juravinski Hospital | Recruiting | Hamilton | Ontario | L8V 1C3 | Canada |
|
| London Health Sciences Centre - University Hospital | Not yet recruiting | London | Ontario | N6A 5A5 | Canada |
|
| Niagara Health System - St. Catharine's Site | Not yet recruiting | St. Catharines | Ontario | L2S 0A9 | Canada |
|
| Hôpital Fleurimont du Centre hospitalier universitaire de Sherbrooke | Not yet recruiting | Sherbrooke | Quebec | J1H 5H3 | Canada |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |