Multimodal Markers of Neurodegenerative Disorders at Presymptomatic Stages

Multimodal Markers of Neurodegenerative Disorders at Presymptomatic Stages

NeuroPrems is a prospective, monocentric, longitudinal, not relating to a medicinal product for human use, non-randomized, non-controlled research. The study mainly aims to identify longitudinal changes and events in multimodal markers of neurodegeneration and neuroinflammation during the presymptomatic phases of neurodegenerative diseases.

1. Inclusion Criteria :

   1. For all participants :

      • Male or female
      • Age ≥ 18 years
      • Signed Informed consent by the subject
      • Affiliated with a social security system or beneficiary of such a regime
      • Ability to undergo an MRI exam with Gadobutrol

   2. For presymptomatic participants only :

      • Absence of a diagnosis of neurodegenerative disease. And at least one of the criteria :
      • Known carrier or relative of a patient carrying a mutation in a causal or at-risk responsible for a neurodegenerative disease
      • Isolated REM sleep behavioral disorder
      • Radiological isolated syndrome
      • Abnormal brain protein aggregates

   3. For controls only :

      • Absence of symptoms or diagnosis of neurodegenerative disease (or criteria corresponding to at risk group)

2. Exclusion Criteria :

   • Clinical symptoms fulfilling the criteria of a neurodegenerative disease (see table in criteria section)
   • Refusal of blood draw or brain MRI
   • MRI contraindication (see criteria section)
   • Known allergy to gadoteric acid
   • Unwillingness to be informed in case of abnormal MRI (with a significant medical anomaly)
   • Pregnancy or breastfeeding. For women in fertile age a urine pregnancy test will be performed before the MRI.
   • Inability to understand information about the protocol
   • Person deprived of their liberty by judicial or administrative decision
   • Person under legal protection (legal guardianship, tutelage or maintenance of justice)
   • Person without any protection and unable to consent
   • Other medical, neurological, psychiatric, or social conditions that in the investigator's opinion are likely to interfere with study conduct.