Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer | NCT06513962 | Trialant

Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer | NCT06513962 | Trialant

Official Title: Triptorelin and Protection of Ovarian Reserve in Adolescents and Young Adults With Cancer
Brief Summary: This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. If the ovaries are not working well or completely shut down, then it will be difficult or impossible to get pregnant in the future. Triptorelin works by blocking certain hormones and causing the ovaries to slow down or pause normal activity. The triptorelin used in this study stays active in the body for 24 weeks or about 6 months after a dose is given. After triptorelin is cleared from the body, the ovaries resume normal activities. Adding triptorelin before the start of chemotherapy treatment may reduce the chances of damage to the ovaries.
Detailed Description: PRIMARY OBJECTIVES:

I. Determine the feasibility of conducting a cross network, multi-site, randomized clinical trial of triptorelin among newly diagnosed adolescent and young adult (AYA) female cancer patients age < 40 years (exclusive of breast cancer).

II. Measure ovarian reserve via anti-Mullerian hormone (AMH) at 2-years post completion of alkylating agent-containing chemotherapy among randomized patients.

SECONDARY OBJECTIVES:

I. Collect information on the longitudinal trajectory of change in AMH and other ovarian hormone levels from cancer diagnosis to 2 years post cancer treatment completion among randomized patients.

II. Determine the feasibility of measuring estrogen deprivation symptoms (i.e., hot flashes, sexual dysfunction) menstrual pattern, and quality of life among randomized patients.

EXPLORATORY OBJECTIVE:

I. Establish a unique cohort of female AYA patients treated with alkylating agent chemotherapy and randomized to receive or not receive triptorelin, that can be followed long-term to study reproductive health concerns and outcomes as well as genetic risk factors for premature menopause.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive triptorelin intramuscularly (IM) up to 14 days prior to or within 7 days after the start of standard chemotherapy. For patients whose chemotherapy exceeds 24 weeks, a second dose of triptorelin may be given 24 weeks after the first dose at the treating physician's discretion. Patients also undergo blood sample collection throughout the study.

ARM B: Patients receive standard chemotherapy. Patients also undergo blood sample collection throughout the study.

After completion of study treatment, patients are followed up at 1 and 2 years.

Ages Eligible for Study: Child (0-17)Adult (18-64)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

< 40 years of age at the time of enrollment

Patient must be a post-menarchal female and report that their initial menstrual period occurred > 6 months prior to enrollment. (Current menstrual status is not part of the inclusion criteria.)

Newly diagnosed with first cancer, exclusive of breast cancer.

Note: Apart from breast carcinoma, other tumor types originating in the breast are permitted (e.g., sarcoma, lymphoma).

Planned treatment must include one or more of the following alkylating agents delivered with curative intent: cyclophosphamide, ifosfamide, procarbazine, chlorambucil, carmustine (BCNU), lomustine (CCNU), melphalan, thiotepa, busulfan, nitrogen mustard, or dacarbazine (DTIC).

Expected cumulative cyclophosphamide equivalent dose (CED):

For patients < 20 years of age at enrollment, the expected alkylator dose must be ≥ 4 g/m^2 cumulative CED calculated according to the equation and specified drugs listed. Dacarbazine is not an eligible drug in this age group.

For patients ≥ 20 years of age and < 35 years old at enrollment, any planned alkylator dose is permitted. Eligible patients must receive at least one of the alkylators listed below that contribute to CED. Dacarbazine is not an eligible drug in this age group.

For patients ≥ 35 years of age at enrollment, any planned alkylator dose is permitted. Eligible patients must receive at least one of the alkylators listed that contribute to CED and/or dacarbazine, which IS an eligible drug in this age group.

Note that CED includes all administration routes: intravenous (IV), oral (PO), IM.

The planned total duration of therapy with eligible alkylators is expected to be completed within one year after enrollment. Note: treatment plans with prolonged maintenance periods extending beyond one year are permitted so long as those maintenance treatments are not expected to contain eligible alkylators.

All patients and/or their parents or legal guardians must sign a written informed consent.

All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.

Exclusion Criteria:

Any planned radiation to the pelvis; or cranial radiation ≥ 30 gray (Gy) to the hypothalamus, inclusive of any total body irradiation (TBI).

Planned bilateral oophorectomy. Note: A participant's desire to pursue alternative fertility preservation procedures (i.e., embryo, oocyte, or ovarian tissue cryopreservation) will be allowed (and in fact encouraged).

Congenital syndromes associated with infertility and decreased ovarian reserve at baseline. For example: Turner's Syndrome, Fragile X premutation carriers, Down syndrome, etc.

Pre-existing seizure disorder, congenital long QT syndrome, pseudotumor cerebri; history of pulmonary embolism, venous thrombosis, or myocardial infarction. Note: Contact study chairs if questions arise about other pre-existing conditions.

Receipt of long acting (depot) GnRH agonists within 6 months before enrollment. In contrast, subcutaneous GnRH agonist used for oocyte retrieval is not an exclusion; oral and other hormonal contraceptive use is also not an exclusion. Note: Please see protocol for the concomitant therapy restrictions for patients during the study treatment period. See protocol for information about oral and other hormonal contractive use during the study treatment period.

Receipt of systemic chemotherapy (except for steroids and intrathecal chemotherapy) more than 7 days prior to study enrollment.

Any prior radiation to the pelvis; or cranial radiation ≥ 30 Gy to the hypothalamus, inclusive of any total body irradiation (TBI).

Patients who are pregnant are not eligible. A pregnancy test is required for female patients of childbearing potential.

Lactating females who plan to breastfeed their infants for the duration of triptorelin therapy (24 weeks per dose).

Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of triptorelin therapy (24 weeks per dose).

Children's Hospital of AlabamaRecruiting

Birmingham, Alabama 35233, United States

Site Public ContactContact

oncologyresearch@peds.uab.edu205-638-9285

Jamie M. AyePrincipal Investigator

University of Alabama at Birmingham Cancer CenterRecruiting

Birmingham, Alabama 35233, United States

USA Health Strada Patient Care CenterRecruiting

Mobile, Alabama 36604, United States

Phoenix Childrens HospitalRecruiting

Phoenix, Arizona 85016, United States

Banner University Medical Center - TucsonRecruiting

Tucson, Arizona 85719, United States

Mercy Hospital Fort SmithRecruiting

Fort Smith, Arkansas 72903, United States

Arkansas Children's HospitalRecruiting

Little Rock, Arkansas 72202-3591, United States

CARTI Cancer CenterRecruiting

Little Rock, Arkansas 72205, United States

City of Hope Comprehensive Cancer CenterRecruiting

Duarte, California 91010, United States

UC San Diego Moores Cancer CenterRecruiting

La Jolla, California 92093, United States

Loma Linda University Medical CenterRecruiting

Loma Linda, California 92354, United States

Mattel Children's Hospital UCLARecruiting

Los Angeles, California 90095, United States

Kaiser Permanente-OaklandRecruiting

Oakland, California 94611, United States

Children's Hospital of Orange CountyRecruiting

Orange, California 92868, United States

Sutter Medical Center SacramentoRecruiting

Sacramento, California 95816, United States

UC San Diego Medical Center - HillcrestSuspended

San Diego, California 92103, United States

Rady Children's Hospital - San DiegoRecruiting

San Diego, California 92123, United States

Children's Hospital ColoradoRecruiting

Aurora, Colorado 80045, United States

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical CenterRecruiting

Denver, Colorado 80218, United States

Connecticut Children's Medical CenterRecruiting

Hartford, Connecticut 06106, United States

Beebe Medical CenterRecruiting

Lewes, Delaware 19958, United States

Beebe South Coastal Health CampusRecruiting

Millville, Delaware 19967, United States

Helen F Graham Cancer CenterRecruiting

Newark, Delaware 19713, United States

Medical Oncology Hematology Consultants PARecruiting

Newark, Delaware 19713, United States

Christiana Care Health System-Christiana HospitalRecruiting

Newark, Delaware 19718, United States

Beebe Health CampusRecruiting

Rehoboth Beach, Delaware 19971, United States

Christiana Care Health System-Wilmington HospitalRecruiting

Wilmington, Delaware 19801, United States

Alfred I duPont Hospital for ChildrenRecruiting

Wilmington, Delaware 19803, United States

Children's National Medical CenterRecruiting

Washington D.C., District of Columbia 20010, United States

Golisano Children's Hospital of Southwest FloridaRecruiting

Fort Myers, Florida 33908, United States

UF Health Cancer Institute - GainesvilleRecruiting

Gainesville, Florida 32610, United States

Memorial Regional Hospital/Joe DiMaggio Children's HospitalRecruiting

Hollywood, Florida 33021, United States

Nemours Children's Clinic-JacksonvilleRecruiting

Jacksonville, Florida 32207, United States

University of Miami Miller School of Medicine-Sylvester Cancer CenterRecruiting

Miami, Florida 33136, United States

Nicklaus Children's HospitalRecruiting

Miami, Florida 33155, United States

Miami Cancer InstituteRecruiting

Miami, Florida 33176, United States

AdventHealth OrlandoRecruiting

Orlando, Florida 32803, United States

Nemours Children's HospitalRecruiting

Orlando, Florida 32827, United States

Nemours Children's Clinic - PensacolaRecruiting

Pensacola, Florida 32504, United States

Tampa General HospitalRecruiting

Tampa, Florida 33606, United States

Saint Joseph's Hospital/Children's Hospital-TampaActive, not recruiting

Tampa, Florida 33607, United States

Saint Mary's Medical CenterRecruiting

West Palm Beach, Florida 33407, United States

Children's Healthcare of Atlanta - Arthur M Blank HospitalRecruiting

Atlanta, Georgia 30329, United States

Kapiolani Medical Center for Women and ChildrenRecruiting

Honolulu, Hawaii 96826, United States

OSF Saint Anthony's Health CenterRecruiting

Alton, Illinois 62002, United States

Rush-Copley Medical CenterSuspended

Aurora, Illinois 60504, United States

Saint Mary's HospitalSuspended

Centralia, Illinois 62801, United States

Lurie Children's Hospital-ChicagoRecruiting

Chicago, Illinois 60611, United States

Northwestern UniversityRecruiting

Chicago, Illinois 60611, United States

University of IllinoisRecruiting

Chicago, Illinois 60612, United States

Carle at The RiverfrontSuspended

Danville, Illinois 61832, United States

Northwestern Medicine Cancer Center KishwaukeeRecruiting

DeKalb, Illinois 60115, United States

Carle Physician Group-EffinghamSuspended

Effingham, Illinois 62401, United States

Northwestern Medicine Cancer Center DelnorRecruiting

Geneva, Illinois 60134, United States

Northwestern Medicine Glenview Outpatient CenterRecruiting

Glenview, Illinois 60026, United States

Northwestern Medicine Grayslake Outpatient CenterRecruiting

Grayslake, Illinois 60030, United States

Northwestern Medicine Lake Forest HospitalRecruiting

Lake Forest, Illinois 60045, United States

Carle Physician Group-Mattoon/CharlestonSuspended

Mattoon, Illinois 61938, United States

SSM Health Good SamaritanRecruiting

Mount Vernon, Illinois 62864, United States

Carle BroMenn Medical CenterRecruiting

Normal, Illinois 61761, United States

Carle Cancer Institute NormalRecruiting

Normal, Illinois 61761, United States

Advocate Children's Hospital-Oak LawnRecruiting

Oak Lawn, Illinois 60453, United States

Northwestern Medicine Orland ParkRecruiting

Orland Park, Illinois 60462, United States

Advocate Children's Hospital-Park RidgeRecruiting

Park Ridge, Illinois 60068, United States

Memorial Hospital EastRecruiting

Shiloh, Illinois 62269, United States

Saint John's HospitalRecruiting

Springfield, Illinois 62702, United States

Southern Illinois University School of MedicineRecruiting

Springfield, Illinois 62702, United States

Carle Cancer CenterSuspended

Urbana, Illinois 61801, United States

Northwestern Medicine Cancer Center WarrenvilleRecruiting

Warrenville, Illinois 60555, United States

Rush-Copley Healthcare CenterSuspended

Yorkville, Illinois 60560, United States

Indiana University/Melvin and Bren Simon Cancer CenterRecruiting

Indianapolis, Indiana 46202, United States

Riley Hospital for ChildrenRecruiting

Indianapolis, Indiana 46202, United States

UI Health Care Mission Cancer and Blood - Ankeny ClinicRecruiting

Ankeny, Iowa 50023, United States

Saint Anthony Regional HospitalRecruiting

Carroll, Iowa 51401, United States

Mercy Cancer Center-West LakesRecruiting

Clive, Iowa 50325, United States

UI Health Care Mission Cancer and Blood - West Des Moines ClinicRecruiting

Clive, Iowa 50325, United States

Greater Regional Medical CenterRecruiting

Creston, Iowa 50801, United States

Blank Children's HospitalRecruiting

Des Moines, Iowa 50309, United States

Iowa Methodist Medical CenterRecruiting

Des Moines, Iowa 50309, United States

UI Health Care Mission Cancer and Blood - Des Moines ClinicRecruiting

Des Moines, Iowa 50309, United States

Broadlawns Medical CenterRecruiting

Des Moines, Iowa 50314, United States

Mercy Medical Center - Des MoinesRecruiting

Des Moines, Iowa 50314, United States

UI Health Care Mission Cancer and Blood - Laurel ClinicRecruiting

Des Moines, Iowa 50314, United States

UI Healthcare Mission Cancer and Blood - Fort DodgeRecruiting

Fort Dodge, Iowa 50501, United States

University of Iowa/Holden Comprehensive Cancer CenterRecruiting

Iowa City, Iowa 52242, United States

UI Healthcare Mission Cancer and Blood - PellaRecruiting

Pella, Iowa 50219, United States

UI Health Care Mission Cancer and Blood - Waukee ClinicRecruiting

Waukee, Iowa 50263, United States

Mercy Medical Center-West LakesRecruiting

West Des Moines, Iowa 50266, United States

The Iowa Clinic PCRecruiting

West Des Moines, Iowa 50266, United States

Central Care Cancer Center - Garden CityRecruiting

Garden City, Kansas 67846, United States

Central Care Cancer Center - Great BendRecruiting

Great Bend, Kansas 67530, United States

Norton Children's HospitalRecruiting

Louisville, Kentucky 40202, United States

Children's Hospital New OrleansRecruiting

New Orleans, Louisiana 70118, United States

Ochsner Medical Center JeffersonRecruiting

New Orleans, Louisiana 70121, United States

Maine Children's Cancer ProgramRecruiting

Scarborough, Maine 04074, United States

MaineHealth Maine Medical Center- ScarboroughRecruiting

Scarborough, Maine 04074, United States

Walter Reed National Military Medical CenterRecruiting

Bethesda, Maryland 20889-5600, United States

Christiana Care - Union HospitalRecruiting

Elkton, Maryland 21921, United States

C S Mott Children's HospitalRecruiting

Ann Arbor, Michigan 48109, United States

University of Michigan Rogel Cancer CenterRecruiting

Ann Arbor, Michigan 48109, United States

Bronson Battle CreekRecruiting

Battle Creek, Michigan 49017, United States

Corewell Health Grand Rapids Hospitals - Butterworth HospitalRecruiting

Grand Rapids, Michigan 49503, United States

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalRecruiting

Grand Rapids, Michigan 49503, United States

Trinity Health Grand Rapids HospitalRecruiting

Grand Rapids, Michigan 49503, United States

Bronson Methodist HospitalRecruiting

Kalamazoo, Michigan 49007, United States

West Michigan Cancer CenterRecruiting

Kalamazoo, Michigan 49007, United States

Beacon Kalamazoo Cancer CenterRecruiting

Kalamazoo, Michigan 49009, United States

Beacon KalamazooRecruiting

Kalamazoo, Michigan 49048, United States

Trinity Health Muskegon HospitalRecruiting

Muskegon, Michigan 49444, United States

Corewell Health Lakeland Hospitals - Niles HospitalRecruiting

Niles, Michigan 49120, United States

Cancer and Hematology Centers of Western Michigan - Norton ShoresSuspended

Norton Shores, Michigan 49444, United States

Corewell Health Reed City HospitalRecruiting

Reed City, Michigan 49677, United States

Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterRecruiting

Saint Joseph, Michigan 49085, United States

Corewell Health Lakeland Hospitals - Saint Joseph HospitalRecruiting

Saint Joseph, Michigan 49085, United States

Munson Medical CenterRecruiting

Traverse City, Michigan 49684, United States

University of Michigan Health - WestRecruiting

Wyoming, Michigan 49519, United States

Children's Hospitals and Clinics of Minnesota - MinneapolisRecruiting

Minneapolis, Minnesota 55404, United States

University of Minnesota/Masonic Cancer CenterRecruiting

Minneapolis, Minnesota 55455, United States

University of Mississippi Medical CenterRecruiting

Jackson, Mississippi 39216, United States

Mercy Oncology and Hematology - Clayton-ClarksonRecruiting

Ballwin, Missouri 63011, United States

Central Care Cancer Center - BolivarRecruiting

Bolivar, Missouri 65613, United States

Cox Cancer Center BransonRecruiting

Branson, Missouri 65616, United States

Mercy Cancer Center - Cape GirardeauRecruiting

Cape Girardeau, Missouri 63703, United States

Siteman Cancer Center at Saint Peters HospitalRecruiting

City of Saint Peters, Missouri 63376, United States

Siteman Cancer Center at West County HospitalRecruiting

Creve Coeur, Missouri 63141, United States

Freeman Health SystemRecruiting

Joplin, Missouri 64804, United States

Mercy Hospital JoplinRecruiting

Joplin, Missouri 64804, United States

Children's Mercy Hospitals and ClinicsRecruiting

Kansas City, Missouri 64108, United States

Lake Regional HospitalRecruiting

Osage Beach, Missouri 65065, United States

Mercy Clinic-Rolla-Cancer and HematologyRecruiting

Rolla, Missouri 65401, United States

Phelps Health Delbert Day Cancer InstituteRecruiting

Rolla, Missouri 65401, United States

Heartland Regional Medical CenterRecruiting

Saint Joseph, Missouri 64506, United States

Mercy Hospital SpringfieldRecruiting

Springfield, Missouri 65804, United States

CoxHealth South HospitalRecruiting

Springfield, Missouri 65807, United States

Mercy Infusion Center - ChippewaRecruiting

St Louis, Missouri 63109, United States

Washington University School of MedicineRecruiting

St Louis, Missouri 63110, United States

Mercy Hospital SouthRecruiting

St Louis, Missouri 63128, United States

Siteman Cancer Center-South CountyRecruiting

St Louis, Missouri 63129, United States

Siteman Cancer Center at Christian HospitalRecruiting

St Louis, Missouri 63136, United States

Mercy Hospital Saint LouisRecruiting

St Louis, Missouri 63141, United States

Mercy Hospital WashingtonRecruiting

Washington, Missouri 63090, United States

Children's Hospital and Medical Center of OmahaRecruiting

Omaha, Nebraska 68114, United States

University of Nebraska Medical CenterRecruiting

Omaha, Nebraska 68198, United States

Hackensack University Medical CenterRecruiting

Hackensack, New Jersey 07601, United States

Presbyterian HospitalRecruiting

Albuquerque, New Mexico 87106, United States

University of New Mexico Cancer CenterRecruiting

Albuquerque, New Mexico 87106, United States

Albany Medical CenterRecruiting

Albany, New York 12208, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterRecruiting

New York, New York 10032, United States

NYP/Weill Cornell Medical CenterRecruiting

New York, New York 10065, United States

University of RochesterRecruiting

Rochester, New York 14642, United States

Stony Brook University Medical CenterRecruiting

Stony Brook, New York 11794, United States

Montefiore Medical Center - Moses CampusRecruiting

The Bronx, New York 10467, United States

UNC Lineberger Comprehensive Cancer CenterRecruiting

Chapel Hill, North Carolina 27599, United States

Duke University Medical CenterRecruiting

Durham, North Carolina 27710, United States

Wake Forest University Health SciencesRecruiting

Winston-Salem, North Carolina 27157, United States

Sanford Bismarck Medical CenterRecruiting

Bismarck, North Dakota 58501, United States

Sanford Broadway Medical CenterRecruiting

Fargo, North Dakota 58122, United States

Children's Hospital Medical Center of AkronRecruiting

Akron, Ohio 44308, United States

Cleveland Clinic FoundationRecruiting

Cleveland, Ohio 44195, United States

Nationwide Children's HospitalRecruiting

Columbus, Ohio 43205, United States

Dayton Children's HospitalRecruiting

Dayton, Ohio 45404, United States

University of Oklahoma Health Sciences CenterRecruiting

Oklahoma City, Oklahoma 73104, United States

Mercy Hospital Oklahoma CityRecruiting

Oklahoma City, Oklahoma 73120, United States

Oregon Health and Science UniversityRecruiting

Portland, Oregon 97239, United States

Christiana Care Health System-Concord Health CenterRecruiting

Chadds Ford, Pennsylvania 19317, United States

Penn State Children's HospitalRecruiting

Hershey, Pennsylvania 17033, United States

Children's Hospital of PhiladelphiaRecruiting

Philadelphia, Pennsylvania 19104, United States

Saint Christopher's Hospital for ChildrenRecruiting

Philadelphia, Pennsylvania 19134, United States

Children's Hospital of Pittsburgh of UPMCRecruiting

Pittsburgh, Pennsylvania 15224, United States

Rhode Island HospitalRecruiting

Providence, Rhode Island 02903, United States

Medical University of South CarolinaRecruiting

Charleston, South Carolina 29425, United States

Prisma Health Richland HospitalRecruiting

Columbia, South Carolina 29203, United States

Sanford USD Medical Center - Sioux FallsRecruiting

Sioux Falls, South Dakota 57117-5134, United States

Saint Jude Children's Research HospitalRecruiting

Memphis, Tennessee 38105, United States

The Children's Hospital at TriStar CentennialRecruiting

Nashville, Tennessee 37203, United States

Vanderbilt University/Ingram Cancer CenterRecruiting

Nashville, Tennessee 37232, United States

Medical City Dallas HospitalRecruiting

Dallas, Texas 75230, United States

Parkland Memorial HospitalRecruiting

Dallas, Texas 75235, United States

UT Southwestern/Simmons Cancer Center-DallasRecruiting

Dallas, Texas 75390, United States

El Paso Children's HospitalRecruiting

El Paso, Texas 79905, United States

Cook Children's Medical CenterRecruiting

Fort Worth, Texas 76104, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterRecruiting

Houston, Texas 77030, United States

UT MD Anderson Cancer CenterRecruiting

Houston, Texas 77030, United States

Children's Hospital of San AntonioRecruiting

San Antonio, Texas 78207, United States

VCU Massey Comprehensive Cancer CenterRecruiting

Richmond, Virginia 23298, United States

Carilion Children'sRecruiting

Roanoke, Virginia 24014, United States

Seattle Children's HospitalRecruiting

Seattle, Washington 98105, United States

Fred Hutchinson Cancer CenterRecruiting

Seattle, Washington 98109, United States

University of Washington Medical Center - MontlakeRecruiting

Seattle, Washington 98195, United States

Providence Sacred Heart Medical Center and Children's HospitalRecruiting

Spokane, Washington 99204, United States

Madigan Army Medical CenterRecruiting

Tacoma, Washington 98431, United States

Saint Vincent Hospital Cancer Center Green BayRecruiting

Green Bay, Wisconsin 54301, United States

Saint Vincent Hospital Cancer Center at Saint Mary'sRecruiting

Green Bay, Wisconsin 54303, United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterRecruiting

Madison, Wisconsin 53718, United States

University of Wisconsin Carbone Cancer Center - University HospitalRecruiting

Madison, Wisconsin 53792, United States

Children's Hospital of WisconsinRecruiting

Milwaukee, Wisconsin 53226, United States

Aurora Sinai Medical CenterRecruiting

Milwaukee, Wisconsin 53233, United States

Saint Vincent Hospital Cancer Center at Oconto FallsRecruiting

Oconto Falls, Wisconsin 54154, United States

Saint Vincent Hospital Cancer Center at SheboyganRecruiting

Sheboygan, Wisconsin 53081, United States

Sheboygan Physicians GroupRecruiting

Sheboygan, Wisconsin 53081, United States

Saint Vincent Hospital Cancer Center at Sturgeon BayRecruiting

Sturgeon Bay, Wisconsin 54235-1495, United States

CancerCare ManitobaRecruiting

Winnipeg, Manitoba R3E 0V9, Canada

The Montreal Children's Hospital of the MUHCRecruiting

Montreal, Quebec H3H 1P3, Canada

Centre Hospitalier Universitaire Sainte-JustineRecruiting

Montreal, Quebec H3T 1C5, Canada

Centre Hospitalier Universitaire de Sherbrooke-FleurimontRecruiting

Sherbrooke, Quebec J1H 5N4, Canada

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)Recruiting

Québec, G1V 4G2, Canada