Comparison of Remimazolam and Propofol on Emergence in Elderly Orthopedic Patients Under General Anesthesia

Comparative Study of Remimazolam, Remimazolam Plus Flumazenil vs Propofol Anesthesia on Emergence Time in Elderly Patients Undergoing Hip Replacement: A Randomized, Double Blinded Controlled Study

Purpose: This study aims to compare the emergence time among three anesthesia regimens: remimazolam, remimazolam with flumazenil, and propofol in elderly patients undergoing hip replacement surgery.

Background: Previous studies have shown that flumazenil accelerates emergence time when used with remimazolam. Remimazolam and propofol have comparable emergence times, although remimazolam can be up to 5 minutes longer than propofol.

Inclusion Criteria:

• Elderly patients (≥65 years old).
• Scheduled for elective hip replacement surgery.
• ASA (ASA, American Society of Anesthesiologists) physical status I-III.
• Able to provide informed consent.

Exclusion Criteria:

• Known hypersensitivity to remimazolam, flumazenil, or propofol.
• Severe hepatic or renal impairment.
• History of benzodiazepine or alcohol abuse.
• Cognitive impairment that may interfere with the ability to provide consent.