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The goal of this observational study is to learn about the influence of extracellular water on volume status in adult sepsis patients presenting with hemodynamic instability. The main question it aims to answer is:
• Can measurement of extracellular water (MoistureMeterD, Delfin Technologies Ltd, Kuopio, Finland) contribute to the description of hemodynamic instability in adult sepsis patients.
Patients with sepsis admitted to intensive care will receive standard care with the addition of measurement of extracellular water.
Adult patients with sepsis admitted to any of our ICUs will be recruited. During the first three days after inclusion blood samples and extended non-invasive monitoring, including monitoring of the microcirculation (CytoCam) and measurement of extracellular water (dielectronic constant), will be added to routine care and monitoring.
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| Measure | Description | Time Frame |
|---|---|---|
| Phenotypes in sepsis - extracellular water for volume status characterization. | Can measurement of extracellular water (MoistureMeterD, Delfin Technologies Ltd, Kuopio, Finland) contribute to the description of hemodynamic instability in adult sepsis patients during the first 72 hours? | 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients admitted to an ICU in Uppsala with suspected or confirmed sepsis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Annelie Barrueta Tenhunen, MD, PhD | Contact | +46728881882 | annelie.barrueta@uu.se |
| Name | Affiliation | Role |
|---|---|---|
| Annelie Barrueta Tenhunen, MD, PhD | Uppsala University, Region Uppsala | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AnOpIva | Recruiting | Uppsala | Uppsa | 75309 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15132310 | Background | Nuutinen J, Ikaheimo R, Lahtinen T. Validation of a new dielectric device to assess changes of tissue water in skin and subcutaneous fat. Physiol Meas. 2004 Apr;25(2):447-54. doi: 10.1088/0967-3334/25/2/004. | |
| 38813316 | Background | Toro C, Markarian B, Mayrovitz HN. Breast Cancer-Related Lymphedema Assessed via Tissue Dielectric Constant Measurements. Cureus. 2024 Apr 29;16(4):e59261. doi: 10.7759/cureus.59261. eCollection 2024 Apr. |
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The data will only be accessible to the research team.
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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Blood samples
| 36457089 | Background | De Backer D, Cecconi M, Chew MS, Hajjar L, Monnet X, Ospina-Tascon GA, Ostermann M, Pinsky MR, Vincent JL. A plea for personalization of the hemodynamic management of septic shock. Crit Care. 2022 Dec 1;26(1):372. doi: 10.1186/s13054-022-04255-y. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |