Determination of the Optimal Nutrient Mix to Acutely Increase Plasma Ketones

Determination of the Optimal Nutrient Mix to Acutely Increase Plasma Ketones

This study will be performed to determine the optimal nutrient mix (predominantly based on medium-chain triglycerides (MCTs)) to induce a mild ketogenic state in healthy older (60-80y), overweight/obese (BMI: 25-35 kg/m2) individuals. Since the aim is to induce a mild ketogenic state, a 25g MCT-based nutrient mix, a 25g MCT-based nutrient mix + cofactors, or a non-ketogenic control will be compared.

Inclusion Criteria:

• Aged 60-80 years
• Body mass index (BMI) 25-35 kg/m2
• Stable dietary habits (no weight loss or gain > 5 kg in the past 3 months)
• Participants are able to provide signed and dated written informed consent prior to any study specific procedures

Exclusion Criteria:

• Type 2 diabetes

• Pre-diabetes based on one or a combination of the following criteria:

  • ImpairedFastingGlucose(IFG):Fasting plasma glucose ≥ 6.1mmol/l and ≤ 6.9 mmol/l.
  • HbA1c of 5.7-6.4%.

• Participants with active congestive heart failure and/or severe renal and or liver insufficiency

• Uncontrolled hypertension

• Alcohol consumption of > 3 servings per day for man and > 2 servings per day for woman

• Unstable body weight (weight gain or loss > 5 kg in the last 3 months)

• Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study results

• Significant food allergies/intolerance (seriously hampering study meals)

• Participants who do not want to be informed about unexpected medical findings

• Blood donation during or within 2 months prior to the study