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Observational study at CDI Cleveland Dental Institute. Investigators will assess the pain perception in one group of patients using two non-invasive methods. First, a numerical rate scale (NRS) and second, a brain wave EEG.
To generate the nociceptive stimulus, The investigators will apply cold (Endo-Ice) to a healthy upper incisor tooth #8. Inclusion criteria: Patients between 20 and 60 years old, with healthy teeth, no history of dental alveolar trauma, and no pulp chamber calcification. After the nociceptive stimulus, patients will write their pain perception on paper from 0 to 10, and at the same time, we will record the brain activity with a non-invasive EEG Emotiv. Then, we will correlate both methods.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| One group of patients between 20-60 years old | Patients between 20-60 years old with a tooth health and no history of dental alveolar trauma or pulp chamber calcification. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EEG EMOTIV | Device | The teeth will be dried with 2x2 gauze; then, Endo Ice will be applied. The patient response will be written on a sheet numbering to choose from 0 to 10, and at the same time, the brain waves will be recorded through EEG. |
| Measure | Description | Time Frame |
|---|---|---|
| Pain Perception Measurement by EEG. | to observe the brain waves changes during pain perception | January 2024-December 2024 |
| Pain Perception Measurement by EEG and NRS. | To establish a possible correlation between the NRS and EEG measurements. | January 2024-December 2024 |
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Inclusion Criteria:
Exclusion Criteria:
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In the outpatient clinic of CDI Cleveland Dental Institute, patients with mature and vital tooth #8 are between 20 and 60 years old.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ulises Carballosa, Resident | Contact | 7866901609 | u.carballosa@cdiohio.org | |
| Dania Mustafa, Resident | Contact | 5038510616 | d.mustafa@cdiohio.org |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cleveland Dental Institute | Recruiting | Cleveland | Ohio | 44128 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28301403 | Background | Alcock MM. Defining pain: past, present, and future. Pain. 2017 Apr;158(4):761-762. doi: 10.1097/j.pain.0000000000000828. No abstract available. | |
| 36397373 | Background | Matsuda S, Itoi H, Ryoke T, Yoshimura H. How should clinicians assess acute dental pain?: A review. Medicine (Baltimore). 2022 Nov 11;101(45):e31727. doi: 10.1097/MD.0000000000031727. |
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| ID | Term |
|---|---|
| D010146 | Pain |
| D014098 | Toothache |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014076 | Tooth Diseases |
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| ID | Term |
|---|---|
| D003791 | Dental Pulp Test |
| ID | Term |
|---|---|
| D003945 | Diagnosis, Oral |
| D003813 | Dentistry |
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| 30462175 | Background | Mouraux A, Iannetti GD. The search for pain biomarkers in the human brain. Brain. 2018 Dec 1;141(12):3290-3307. doi: 10.1093/brain/awy281. |
| 35659993 | Background | Mussigmann T, Bardel B, Lefaucheur JP. Resting-state electroencephalography (EEG) biomarkers of chronic neuropathic pain. A systematic review. Neuroimage. 2022 Sep;258:119351. doi: 10.1016/j.neuroimage.2022.119351. Epub 2022 Jun 2. |
| 28025007 | Background | Ploner M, Sorg C, Gross J. Brain Rhythms of Pain. Trends Cogn Sci. 2017 Feb;21(2):100-110. doi: 10.1016/j.tics.2016.12.001. Epub 2016 Dec 23. |
| 30260531 | Background | May ES, Nickel MM, Ta Dinh S, Tiemann L, Heitmann H, Voth I, Tolle TR, Gross J, Ploner M. Prefrontal gamma oscillations reflect ongoing pain intensity in chronic back pain patients. Hum Brain Mapp. 2019 Jan;40(1):293-305. doi: 10.1002/hbm.24373. Epub 2018 Sep 10. |
| 68872 | Background | Holsheimer J, Feenstra BW. Volume conduction and EEG measurements within the brain: a quantitative approach to the influence of electrical spread on the linear relationship of activity measured at different locations. Electroencephalogr Clin Neurophysiol. 1977 Jul;43(1):52-8. doi: 10.1016/0013-4694(77)90194-8. |
| D009057 | Stomatognathic Diseases |
| D005157 | Facial Pain |