Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. The investigators aimed to examine plasma creatine phosphokinase (CPK) levels to see whether myotoxicity occurs or not after fascial plane blocks are applied to patients undergoing laparoscopic cholecystectomy.

During 3 months period all elligible patients undergoing laparoscopic cholecystectomy surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma creatin phosphokinase (CPK) levels will be tested 3 times of all patients(preoperative, postoperative 6th hour, postoperative 24th hour). Data will be analysed and patients will be grouped according to the analgesic modalities used.

Inclusion Criteria:

• ASA 1-3
• Laparoscopic cholecystectomy
• under General Anesthesia

Exclusion Criteria:

• Morbidly obesity or cachexia
• local anesthetic allergies
• myopathies
• coagulopathies
• Obstructive sleep apne syndrome
• hearth diseases
• liver diseases
• kidney diseases
• thyroid-parathyriod dieseas
• hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
• pregnancy

patients who underwent laparoscopic cholecystectomy ASA 1-3. age:18-70