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This study aims to determine the levels of NLRP3, caspase-1 and IL-1β concentrations in the gingival crevicular fluid of paediatric patients with gingivitis and their changes after periodontal treatment.
After being informed about the study and potential risks, necessary periodontal measurements will be performed and gingival crevicular fluid will be collected from all patients who gave written informed consent, and patients with gingivitis will be followed up on the 7th and 30th day after periodontal treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gingivitis Group | Experimental | In the first session, gingival crevicular fluid samples will be taken from teeth numbered 11,21, periodontal measurements will be made, plaques on the teeth will be cleaned and oral hygiene training will be performed. On the 7th and 30th days, gingival crevicular fluid will be taken again and periodontal measurements will be made. |
|
| Healthy Group | No Intervention | Gingival crevicular fluid samples will be taken from teeth numbered 11,21, periodontal measurements will be made |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Periodontal theraphy | Procedure | periodontal therapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| NLRP3 | NOD-, LRR- and pyrin domain-containing protein 3 level | Baseline |
| Caspase-1 | Caspase-1 level | Baseline |
| IL-1 Beta | Interleukin-1 Beta level | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| NLRP3 | NOD-, LRR- and pyrin domain-containing protein 3 level | 7. days - 30. days |
| Caspase-1 | Caspase-1 level | 7. days -30. days |
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Inclusion Criteria:
Inclusion criteria for the group with gingivitis;
Inclusion criteria for the healthy group;
Exclusion Criteria
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sultan Keleş, Assoc.Prof. | Contact | 05318438557 | +90 | dtsultank@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sultan Keles | Recruiting | Aydin | 09100 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D005891 | Gingivitis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
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| IL-1 Beta | Interleukin-1 Beta level | 7. days-30. days |
| D009057 |
| Stomatognathic Diseases |