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The goal of this observational study focuses on the effect of different preoperative anemia status on perioperative complications in patients under moderate- to high-risk surgery. Different anemia types conclude iron-deficiency anemia(IDA), anemia of chronic disease/anemia of inflammation(ACD/AI), and combined anemia.The main question it aims to answer is whether there is a difference in the incidence of complication related to oxygen supply and demand imbalance in patients with IDA, ACD/AI or combined anemia.
Patients without preoperative anemia will be recruited as the control group for secondary outcome analysis, which is whether there is a difference in the incidence of complication related to oxygen supply and demand imbalance in patients with or without anemia.
The investigators aim to screen patients according to including and excluding criteria. According to the hemoglobin level, if the patient is anemia, the investigators will offer some lab tests for serum iron, transferrin saturation, C-reactive protein to classify different anemia status. Besides, the investigators will include patients without anemia in a 2:1 ration of anemia to non-anemia. The perioperative assessment and follow-up are the same for all the included patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IDA | patients with iron-deficiency anemia | ||
| ACD/AI | patients with anemia of chronic disease/anemia of inflammation | ||
| Combined anemia | patients with IDA and ACD/AI |
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| Measure | Description | Time Frame |
|---|---|---|
| postoperative complications related to oxygen supply and demand imbalance | The occurrence of any of the following complications is considered a positive outcome, which include myocardial injury after non cardiac surgery(MINS), acute kidney injury(AKI), neurological damage such as stroke and delayed neurocognitive recovery(DNR) | before discharge or until seven days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of post complications related to oxygen supply and demand imbalance in patients with or without anemia | The occurrence of any of the following complications is considered a positive outcome, which include myocardial injury after non cardiac surgery(MINS), acute kidney injury(AKI), neurological damage such as stroke and delayed neurocognitive recovery(DNR) | before discharge or seven days after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who are 18 years or older scheduled for moderate- or high-risk surgery will be included in our study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lu Che | Contact | 15901045120 | tracymaobao@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology, First Affiliated Hospital of Wannan Medical College | Recruiting | Wuhu | Anhui | China |
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| ID | Term |
|---|---|
| D000740 | Anemia |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| Postoperative functional disability | The World Health Organization Disability Assessment Schedule 2.0 (WHO DAS2.0) is used for disability assessment. | 1 month, 6 months and 1 year after surgery |
| Cognitive function decline | The modified Telephone Interview for Cognitive Status(TICS-m) is used for cognitive function assessment. | 1 month, 6 months and 1 year after surgery |
| RBC Transfusion rate | The above information can be got according to the medical record | From date of surgery until discharge day, assessed up to 4 weeks |
| Length of hospital stay | The above information can be got according to the medical record | From date of surgery until discharge day, assessed up to 4 weeks |
| Severe complication | Evaluated according to Clavien-Dindo classification, level three to five are defined as severe complication. | before discharge, 1 month, 6 months and 1 year after surgery |
| Beijing Longfu Hospital (Beijing Geriatric Hospital of Integrated Traditional Chinese and Western Medicine) | Recruiting | Beijing | Beijing Municipality | 100010 | China |
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| Anesthesiology Department, Beijing NO.6 Hospital | Recruiting | Beijing | Beijing Municipality | China |
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| BeiJing Hepingli Hospital | Recruiting | Beijing | Beijing Municipality | China |
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| Beijing Puren Hospital | Recruiting | Beijing | Beijing Municipality | China |
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| Peking Union Medical College Hospital | Recruiting | Beijing | Beijing Municipality | China |
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| Science and Education Department, Zhangzhou Municipal Hospital of Fujian Province | Recruiting | Zhangzhou | Fujian | China |
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| Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University | Recruiting | Zunyi | Guizhou | 563003 | China |
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| Department of Anesthesiology, Chifeng Municipal Hospital | Recruiting | Chifeng | Inner Mongolia | China |
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| Department of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University | Recruiting | Hohhot | Inner Mongolia | China |
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| Inner Mongolia People's Hospital | Recruiting | Hohhot | Inner Mongolia | China |
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