Postoperative analgesic treatment methods are applied to patients who have undergone knee arthroplasty. These applications are a routine part of the procedure. It is medically and ethically necessary. Postoperative analgesia applications are started during the intraoperative period and continued during the postoperative period. The analgesia protocol to be used is shaped by the characteristics of the patient and the skill and experience of the anesthesiologist. The scientifically accepted method is multimodel analgesia protocols. These protocols cover a wide range from paracetamol to opioids to peripheral and central blocks (methods such as suprainguinal fascia iliac block (SFIP), adductor block (ACB) and infiltration analgesia (IPACK) applied between the posterior elements of the knee and the popliteal artery). Our aim in this study is to evaluate the effects of analgesia protocols applied to patients undergoing knee arthroplasty surgery on inflammatory biomarkers (such as neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), systemic immune inflammation score (SII), lactate) obtained from routine blood and blood gas examinations in the first 24 hours of the postoperative period.

Inclusion Criteria:

• 18-75 years old
• ASA I,II,III patients
• Patients who will undergo elective surgery

Exclusion Criteria:

• Patients undergoing emergency surgery
• Patients with bleeding diathesis
• Those who are allergic or sensitive to local anesthetics and opioid drugs,
• Those who use gabapentinoids
• Patients with neurocognitive disorders,
• Patients with chronic organ failure,
• Mothers with suspected pregnancy, pregnant or breastfeeding mothers
• Patients using opioids
• Those who use steroids
• Those with a history of substance use

Among patients who had elective knee replacement surgery, those who underwent postoperative nerve block

Participants' data will not be shared. After the study is written as an article, it can be shared if the editor of the journal wishes