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Post dural puncture headache is a distressing issue, many measures tried to treat symptoms but few delt with prevention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Placebo Comparator | intravenous 50 mL of sterile saline 0.9% injection of 0.9% after umbilical cord clamping. |
|
| Neostgmine group | Active Comparator | Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping. | Drug | intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of patients with post dural puncture headache | Number of patients develop post dural puncture headache | first 5 days post-partum |
| Measure | Description | Time Frame |
|---|---|---|
| Severity of post dural puncture headache | Visual analogue scale score for pain assessment. from 0 to ten. 0= no pain 1-3= mild pain....4-6= moderate pain ... 7-10= severe pain | first 5 days post-partum |
| onset and duration of post dural puncture headache |
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Inclusion Criteria:
Exclusion Criteria:
We target obstetric population
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| Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping. | Drug | Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping. |
|
Time when visual analogue scale score increase and duration until return to 0. Visual analogue scale score for pain assessment. from 0 to ten. 0= no pain 1-3= mild pain....4-6= moderate pain ... 7-10= severe pain |
| 5 days post partum |
| Analgesic request | First time to analgesic request from block | 24 hours after operation |
| Analgesc requirements | Total analgesic requirements | 2 days after operation |
| frequency of analgesic doses | number of analgesic doses given to the patient | 5 days |
| incidence of complications related to the procedure | number of patients with adverse events as bradycardia, tachcardia, miosis,muscle cramps, twitches, colics, hypotension | 6 hours after procedure |
| ID | Term |
|---|---|
| D059787 | Acute Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D009388 | Neostigmine |
| D001285 | Atropine |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D050338 | Phenylammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D009861 | Onium Compounds |
| D001286 | Atropine Derivatives |
| D014326 | Tropanes |
| D053961 | Azabicyclo Compounds |
| D001372 | Aza Compounds |
| D001533 | Belladonna Alkaloids |
| D012991 | Solanaceous Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D019086 | Bridged Bicyclo Compounds, Heterocyclic |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
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