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The goal of this clinical trial is to learn if dietary supplements containing vitamin and unsaturated fatty acid works to intervene T cell inflammatory factor expression in patients with uveitis and healthy subjects in adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitamin A treatment | Experimental |
| |
| Monounsaturated fatty acid mixture | Experimental |
| |
| Polyunsaturated fatty acid mixture | Experimental |
| |
| Fatty acid mixture | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin A treatment | Dietary Supplement | Vitamin A, 32 microgram per kilograms (of body weight) per day, for three weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory factors-Interleukin-17A (IL-17A) | Flow cytometry analysis of peripheral blood mononuclear cells (PBMCs) to detect the ratio of Interleukin-17A (IL-17A) -producing cells in CD4+ T cells and CD8+ T cells | 3 weeks |
| Inflammatory factors-Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) | Flow cytometry analysis of peripheral blood mononuclear cells (PBMCs) to detect the ratio of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) -producing cells in CD4+ T cells and CD8+ T cells | 3 weeks |
| Inflammatory factors-Interferon gamma (IFN-γ) | Flow cytometry analysis of peripheral blood mononuclear cells (PBMCs) to detect the ratio of Interferon gamma (IFN-γ) -producing cells in CD4+ T cells and CD8+ T cells | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Cytokine levels-Interleukin-17A (IL-17A) | Analysis of cytokine levels in blood. Detect the concention of Interleukin-17A (IL-17A) in plasma | 3 weeks |
| Cytokine levels-Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) |
| Measure | Description | Time Frame |
|---|---|---|
| Transcriptomics analysis | Analyze the changes in peripheral blood mononuclear cells using transcriptomics. Detect the cell populations , genes number and expression. | 3 weeks |
| Proteomics analysis | Analyze the changes in peripheral blood mononuclear cells using proteomics. Detect the proteins expression. |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tianjin Medical University Eye Hospital | Tianjin | Tianjin Municipality | 300071 | China |
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| ID | Term |
|---|---|
| D014605 | Uveitis |
| D001327 | Autoimmune Diseases |
| ID | Term |
|---|---|
| D014603 | Uveal Diseases |
| D005128 | Eye Diseases |
| D007154 | Immune System Diseases |
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| Monounsaturated fatty acid mixture | Dietary Supplement | Monounsaturated fatty acid mixture (mainly Omega-7, Omega-9), 47 milligrams per kilogram (of body weight) per day, for three weeks |
|
| Polyunsaturated fatty acid mixture | Dietary Supplement | Polyunsaturated fatty acid mixture (mainly Omega-3, Omega-6), 6 milligrams per kilogram (of body weight) per day, for three weeks |
|
| Fatty acid mixture | Dietary Supplement | Fatty acid mixture (mainly saturated fatty acid, Omega-6, Omega-7, Omega-9), 83 milligrams per kilogram (of body weight) per day, for three weeks |
|
Analysis of cytokine levels in blood. Detect the concention of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in plasma
| 3 weeks |
| Cytokine levels-Interferon gamma (IFN-γ) | Analysis of cytokine levels in blood. Detect the concention of Interferon gamma (IFN-γ) in plasma | 3 weeks |
| Cytokine levels-Interleukin-2 (IL-2) | Analysis of cytokine levels in blood. Detect the concention of Interleukin-2 (IL-2) in plasma | 3 weeks |
| Cytokine levels-Interleukin-10 (IL-10) | Analysis of cytokine levels in blood. Detect the concention of Interleukin-10 (IL-10) in plasma | 3 weeks |
| Cytokine levels-Interleukin-9 (IL-9) | Analysis of cytokine levels in blood. Detect the concention of Interleukin-9 (IL-9) in plasma | 3 weeks |
| Cytokine levels-Interleukin-4 (IL-4) | Analysis of cytokine levels in blood. Detect the concention of Interleukin-4 (IL-4) in plasma | 3 weeks |
| Cytokine levels-Tumor Necrosis Factor alpha (TNF-α) | Analysis of cytokine levels in blood. Detect the concention of Tumor Necrosis Factor alpha (TNF-α) in plasma | 3 weeks |
| 3 weeks |
| post-translational modification proteomics analysis | Analyze the changes in peripheral blood mononuclear cells using post-translational modification proteomics. Detect the protein various modification, such as lactylation, crotonylation, palmitoylation and methylation. | 3 weeks |
| metabolomics analysis | Analyze the changes in peripheral blood mononuclear cells using metabolomics. Detect the metabolites numbers, localization and level. | 3 weeks |